抗环瓜氨酸肽抗体和类风湿因子联合检测对类风湿关节炎合并间质性肺疾病的临床意义

目的探讨类风湿关节炎合并间质性肺疾病(RA-ILD)的临床特点,为早期发现并诊断RA-ILD提供依据。方法选取2017年7月-2018年6月本院收治的类风湿关节炎患者共61例。根据RA患者是否合并间质性肺疾病,分为观察组RA-ILD和对照组RA,分析比较2组临床资料是否有统计学差异,包括发病年龄、病程、类风湿因子(RF)、抗环瓜氨酸肽抗体(CCP)、C-反应蛋白(CRP)、红细胞沉降率(ESR)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、血小板(Plt)、血红蛋白(Hb)。结果RA-ILD组的发病年龄比RA组早,CCP、CRP、ESR、IgG均比RA组水平高(P<0.05),而2组在性别、病程长短、RF、IgM、IgA、Plt、Hb水平的差异无统计学意义(P>0.05)。结论RA患者中发病年龄早及CCP、CRP、ESR、IgG水平高的患者,易并发肺间质疾病。

Clinical significance of combined detection of anti-CCP and RF in diagnosis of rheumatoid arthritis with interstitial lung disease

Objective To explore the clinical significance of combined detection of anti-CCP and RF in the diagnosis of rheumatoid arthritis with interstitial lung disease.Methods A total of 61 patients with rheumatoid arthritis admitted to our hospital from July 2017 to June 2018 were selected.According to whether RA patients is with interstitial lung diseases or not,all the patients were divided into RA-ILD observation group and RA control group;clinical data of two groups are compared,including age,course of disease,and rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(anti-CCP),c-reactive protein(CRP),erythrocyte sedimentation rate(ESR),immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA),platelet(Plt),hemoglobin(Hb).Results The onset age of RA-ILD group is earlier than that in RA group,the levels of anti-CCP,CRP,ESR,IgG are higher than that in RA group(P<0.05);there was no statistical significance on the difference in gender,duration of disease,rheumatoid factor(RF),immunoglobulin M(IgM),immunoglobulin A(IgA),platelet(Plt),and hemoglobin(Hb)levels between the two groups(P>0.05).Conclusion Patients with early onset of RA and high levels of CCP,CRP,ESR and IgG are prone to pulmonary interstitial disease.