人类脐带Wharton's jelly来源的基质细胞

人类脐带Wharton's jelly来源的基质细胞具有干细胞潜能.它们和骨髓来源的间充质干细胞表达一些共有的表面标志物,具有较高的分化率和自我再生能力,能分化成神经细胞、心肌细胞、内皮细胞、脂肪细胞、软骨细胞及成骨细胞.许多实验表明,人类脐带Wharton's jelly来源的基质细胞在再生治疗方面有广阔的应用前景.对其分离和培养的方法及其体外分化和体内外移植实验做一简明综述.

Human umbilical cord stromal cells derived from Wharton's jelly

Human umbilical cord stromal cells derived from Wharton's jelly bear the potential of stem cells. They share the common surface markers with mesenchymal stem cells derived from bone marrow. They have a relatively higher proliferation rate and self-renewal capacity and can be successfully differentiated into mature neurons, cardiomyocytes, endothelial, adipocytes, chondrocytes and skeletal cells. Researches have shown their promising foregrounds in regenerative therapeutic applications. This article will give a review about the separation and cultivation methods, in vitro differentiation, and in vitro and in vivo transplantation experiments of the aforementioned stromal cells.