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| 马蓝的化学成分研究 | |
| 引用本文： | 李玲,梁华清,廖时萱,乔传卓,杨根金,董同义. 马蓝的化学成分研究[J]. 药学学报, 1993, 28(3): 238-240 |
| 作者姓名： | 李玲 梁华清 廖时萱 乔传卓 杨根金 董同义 |
| 作者单位： | 第二军医大学药学院，第二军医大学药学院，第二军医大学药学院，第二军医大学药学院，第二军医大学药学院，第二军医大学药学院 上海 200433，上海 200433，上海 200433，上海 200433，上海 200433，上海 200433 |
| 摘 要： | Seven compounds have been isolated from the whole plant of Strobilanthes cusia (Nees) O. Ktze. Three of them are triterpenes (Ⅰ～Ⅲ), two are indole alkaloids (Ⅳ, Ⅴ), two are quinazolinone alkaloids (Ⅵ, Ⅶ). On the basis of spectral analysis and physicochemical properties, their structures were established as lupeol (Ⅰ), betulin (Ⅱ), lupenone (Ⅲ), indigo (Ⅳ), indirubin (Ⅴ), 4 (3H)-quinazolinone (Ⅵ), 2, 4 (1H, 3H)-quinazolinedione (Ⅶ). Ⅵ and Ⅶ were found from natural plant for the first time.The results of the pharmacological tests demonstrate that compound Ⅴ has anticancer activity and compound Ⅵ has hypotensive action. Compound Ⅶ can be quantitatively determined by HPLC, which may serve as a quality control standard for materia medica and its preparations. Compounds Ⅵ and Ⅶ have been confirmed by means of synthesis. |
| 关 键 词： | 马蓝 4(3H)-喹唑酮 2,4(1H,3H)-喹唑二酮 |
| 收稿时间： | 1992-03-16 |
CHEMICAL STUDIES OF STROBILANTHES CUSIA |
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| L LI,HQ Liang,SX Liao,CZ Qiao,GJ Yang and TY Dong. CHEMICAL STUDIES OF STROBILANTHES CUSIA[J]. Acta pharmaceutica Sinica, 1993, 28(3): 238-240 | |
| Authors: | L LI HQ Liang SX Liao CZ Qiao GJ Yang TY Dong |
| Abstract: | Seven compounds have been isolated from the whole plant of Strobilanthes cusia (Nees) O. Ktze. Three of them are triterpenes (Ⅰ～Ⅲ), two are indole alkaloids (Ⅳ, Ⅴ), two are quinazolinone alkaloids (Ⅵ, Ⅶ). On the basis of spectral analysis and physicochemical properties, their structures were established as lupeol (Ⅰ), betulin (Ⅱ), lupenone (Ⅲ), indigo (Ⅳ), indirubin (Ⅴ), 4 (3H)-quinazolinone (Ⅵ), 2, 4 (1H, 3H)-quinazolinedione (Ⅶ). Ⅵ and Ⅶ were found from natural plant for the first time.The results of the pharmacological tests demonstrate that compound Ⅴ has anticancer activity and compound Ⅵ has hypotensive action. Compound Ⅶ can be quantitatively determined by HPLC, which may serve as a quality control standard for materia medica and its preparations. Compounds Ⅵ and Ⅶ have been confirmed by means of synthesis. |
| Keywords: | Strobilanthes cusia (Nees) O Ktze. 4-(3H) Quinazolinone 2 4(1H 3H) Quinazolinedione |
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