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| 高糖对体外培养背根神经节神经元影响的研究进展 | |
| 引用本文： | 孙青,梁晓春,张宏. 高糖对体外培养背根神经节神经元影响的研究进展[J]. 基础医学与临床, 2011, 31(2) |
| 作者姓名： | 孙青 梁晓春 张宏 |
| 作者单位： | 1. 中国医学科学院,北京协和医学院北京协和医院,中医科,北京,100730 2. 中国医学科学院,北京协和医学院基础医学研究所,细胞中心,北京,100005 |
| 摘 要： | 背根神经节神经元(DRGn)在糖尿病周围神经病变发展过程中起重要作用,近年来探讨高糖对体外培养背根神经节神经元(DRGn)的影响成为研究热点.高糖环境可致DRGn细胞凋亡;同时高糖环境下DRGn在氧化应激、膜受体mGluRs及TRPV1激活、DRGn/SCs共培养等方面均与正常培养基不同,具体机制仍需深入研究. |
| 关 键 词： | 背根神经节神经元 高糖 细胞培养 体外 |
Progress in the study of the effects of high glucose on dorsal root ganglion neurons in vitro |
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| SUN Qing,LIANG Xiao-chun,ZHANG Hong. Progress in the study of the effects of high glucose on dorsal root ganglion neurons in vitro[J]. Basic Medical Sciences and Clinics, 2011, 31(2) | |
| Authors: | SUN Qing LIANG Xiao-chun ZHANG Hong |
| Affiliation: | SUN Qing1,LIANG Xiao-chun1,ZHANG Hong2 (1.Dept of Traditional Chinese Medicine,PUMC Hospital,Beijing 100730,2.Dept.of Cell Center,IBMS,CAMS & PUMC,Beijing 100005,China) |
| Abstract: | Dorsal root ganglion neurons(DRGn) play an important role in diabetic peripheral neuropathy.Currently,the effects of high glucose level on DRGn in vitro has become a research hotspot.High glucose level results in apoptosis of DRGn.Moreover,DRGn showed differences in oxidative stress,activation of membrane receptor mGluRs and TRPV1,DRGn/SCs co-cultures between in high glucose and in defined medium. |
| Keywords: | dorsal root ganglion neurons high glucose cell culture in vitro |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |