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| 腺苷对豚鼠左心室流出道自律细胞的电生理效应 | |
| 引用本文： | 赵兰平,李建东,商爱民,牛欣.腺苷对豚鼠左心室流出道自律细胞的电生理效应[J].基础医学与临床,2011,31(2). |
| 作者姓名： | 赵兰平 李建东 商爱民 牛欣 |
| 作者单位： | 1. 河北北方学院生理教研室,河北,张家口,075000 2. 河北北方学院教务处,河北,张家口,075000 3. 北京中医药大学生理教研室,北京,100029 |
| 基金项目： | 河北省科学技术研究与发展计划 |
| 摘 要： | 目的 研究腺苷对豚鼠左心室流出道自律性电活动及其对肾上腺素、低氧和酸中毒电生理效应的影响.方法 采用玻璃微电极细胞内电位记录技术,分别观察腺苷对左心室流出道自发慢反应电位及对肾上腺素、低氧和酸中毒所致该电位改变的影响.结果 (1)10、50及100 μmol/L腺苷可呈剂量依赖性降低豚鼠左心室流出道自律细胞的电活动.(2)10 ixmol/L肾上腺素可明显提高左心室流出道的自律性,50μmol/L腺苷明显降低肾上腺素导致的该部位自律性升高.(3)低氧和酸中毒均可使该部位的自律性电活动明显降低,50μmol/L腺苷可使其自律性进一步降低.结论 腺苷对左心室流出道的自律性及肾上腺素、低氧和酸中毒导致的自律性异常有一定影响. |
| 关 键 词： | 腺苷 左心室流出道 自律细胞 电生理效应 |
Electrophysiological effects of adenosine on pacemaker cells in guinea-pig left ventricular outflow tract |
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| ZHAO Lan-ping,LI Jian-dong,SHANG Ai-min,NIU Xin.Electrophysiological effects of adenosine on pacemaker cells in guinea-pig left ventricular outflow tract[J].Basic Medical Sciences and Clinics,2011,31(2). | |
| Authors: | ZHAO Lan-ping LI Jian-dong SHANG Ai-min NIU Xin |
| Institution: | ZHAO Lan-ping1,LI Jian-dong1,SHANG Ai-min2,NIU Xin3(1.Dept of Physiology,2.Dean's Office,Hebei North University,Zhangjiakou 075000,3.Dept of Physiology,Beijing University of Chinese Medicine,Beijing 100029,China) |
| Abstract: | Objective To investigate the effects of adenosine on spontaneous action potentials of left ventricular outflow tract and the effects of adenosine on epinephrine,hypoxia and acidosis.Methods By using conventional intracellular microelectrode technique to record action potentials,adenosine was used to study the electrophysiological effects on pacemaker cells in ventricular outflow tract.The effects of adenosine on epinephrine,hypoxia and acidosis were also studied.Results(1)Adenosine significantly decreased t... |
| Keywords: | adenosine left ventricular outflow tract pacemaker cells electrophysiological effects |
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