氟比洛芬酯注射液的镇痛抗炎作用评价

【目的】研究氟比洛芬酯注射液的镇痛抗炎作用。【方法】通过小鼠醋酸扭体和大鼠福尔马林炎性痛模型评价氟比洛芬酯注射液的镇痛抗炎作用。【结果】在小鼠醋酸扭体模型上,与空白组相比,尾静脉给予20、40和80 mg/kg的氟比洛芬酯注射液(Flurbiprofen Axetil Injection,Flu-A)均能够显著抑制小鼠扭体次数,具有较好的镇痛作用;在大鼠福尔马林炎性痛模型上,Flu-A(40和80 mg/kgi,.v.)能够显著降低大鼠的缩足次数和右足足肿胀程度,表现出较好的镇痛抗炎作用。此外,Flu-A在80mg/kg剂量下的镇痛强度与阿司匹林相当。【结论】氟比洛芬酯注射液具有一定的镇痛抗炎作用。

Evaluation on the analgesic and anti-inflammatory effect of flurbiprofen axetil Injection

【Objective】To estimate the analgesic and anti-inflammatory effects of Flurbiprofen Axetil Injection（Flu-A）.【Methods】Acetic acid-induced mouse writhing model and formalin induced rat paw edema models were used to study the analgesic and anti-inflammatory effects of Flu-A.【Results】The results of the acetic acid-induced writhing behaviour in mice showed that Flu-A at 20,40 and 80 mg/kg could significantly reduce the writhing numbers as compared with control group,and indicated that Flu-A had analgesic activity.The results of the formalin test showed that Flu-A at 40 and 80 mg/kg could significantly reduce the flinch numbers and volume of right pawas compared with control group and showed peripheral analgesic and anti-inflammatory activity.The analgesic effect of Flu-A at 80 mg/kg were comparable with aspirin.【Conclusion】Flu-A have certain analgesic and anti-inflammatory activity.