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| EFFECTS OF LIUWEIDIHUANG WAN AND SOME OTHER TCM DRUGS ON BONE BIOMECHANICS AND SERUM 25(OH)D_(3) CONTENT IN RATS | |
| 作者姓名： | 陈燕平 瞿长安 钟洪刚 薛延 周重光 李文菁 陈训华 |
| 作者单位： | Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700，Institute of Orthopedics and Traumatology China Academy of Traditional Chinese Medicine Beijing 100700 |
| 摘 要： | After a relatively long-term injection of hydrocortisone into rats, the strength of bone (anti-stress capacity) reduced evidently, while the rigidity (anti-deformity capacity) in-creased markedly (ie, bone fragility elevated). At the same time, the content of serum 25(OH)D3 decreased remarkably. After oral administration of Liuwei Dihuang Wan (六味地黄丸), anti-stress capability of bone increased evidently and its anti-deformity capability returned to normal; however, there was no elevation of serum 25(OH)D3 content The ef-fect of Longmu Zhuanggu Chongji (龙牡壮骨冲剂) or Jisheng Shenqi Wan (济生肾气丸) was lower than that of Linwei Dihuang Wan. The experiments suggest that Liuwei Dihuang Wan is beneficial to preventing and curing osteoporosis, but no correlation between its mechanism and the metabolism of 25(OH)D3 was demonstrated. |
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