乌司他丁对大面积烧伤休克期治疗的临床研究

目的 探讨乌司他丁对大面积烧伤休克期的治疗效果。方法 将15例大面积烧伤患者随机分为两组，其中8例行休克期早期应用乌司他丁治疗（以下简称治疗组），另7例行休克期常规治疗（以下简称对照组）。观察两组患者伤后第4天生命体征、尿量、休克持续时间及并发症等指标的变化。结果 治疗组比对照组患者伤后第4天生命体征平稳，尿量正常或偏多，休克持续时间短，并发症少。结论大面积烧伤休克期及早应用乌司他丁能够显著抑制机体过度的炎性反应，减少氧自由基释放，降低血清超氧化物歧化酶（SOD）消耗，从而减轻创伤对机体器官的损伤，改善休克期机体存在的缺血-再灌注损伤，使机体能够及早平稳度过休克期，为下一步切（削）痂手术植皮等治疗打下了坚实的基础。

Clinical effects of ulinastatin in treating extensive burns patients of shock period

Objective To investigate the clinical effects of ulinastatin in treating extensive burns patients of shock period.Methods 15 patients with extensive burns were assigned to the treatment group(8 eases)and the control group(7 cases)randomly,patients in the control group were given the routine therapy,while those in the treatment group Were also given ulinastatin in the early stage of shock period.The life symptoms,urine amount, shock lasting time and complications were observed in the fourth day after injury.Results Compared to the control group,the life symptoms were steadier,urine amount was more of equivalent,shock lasting time was shorter,and complications were less in the treatment group.Conclusion In the early stage of the shock period for extensive burns patients,ulinastatin can help the patients live through the shock period steady.