2型糖尿病肾病患者血浆脂蛋白及尿微量蛋白的变化

目的：通过检测2型糖尿病患者脂蛋白及尿微量蛋白水平，为糖尿病肾病的早期诊断与预防提供依据。方法：按病程将糖尿病肾病病人分成三组：采用全自动生化分析仪检测空腹血糖、糖化血红蛋白（HbAlc）、血浆脂蛋白、肾功能及尿微量蛋白水平。结果：B组及c组病人之和占总糖尿病肾病病人71．43％，且年龄较大（P〈0．05）；病程较短的糖尿病肾病病人空腹血糖高于其它各组（P〈0．01），TG、LDL-C、APOB及LPA高于病程较长组，且三组都低于单纯糖尿病组，而肾功能各项及尿微量蛋白均高于单纯糖尿病组（P〈0．01），CysC水平无统计学意义（P〉0．05）。结论：糖尿病肾病患者存在糖及脂蛋白代谢紊乱，尿微量蛋白结合血脂检测有利于早期发现肾脏损伤。

The changes of plasma lipoprotein in serum and urine minim protein in type 2 diabetic nephropathy

Objective：To supply the basis tor early diagnosis and prevention oi type 2 diabetic nephropathy by detecting the lebel of plasma lipoprotein and urine minim protein （UMPR） in patients. Methods：The patients were di- vided three groups by the course of diabetic： The fasting blood-glucose （FBG）, HbAlc, plasma lipoprotein, BUN, Scr, UA, CysC and UMPR were detected by automatic biochemical analyzer. Results：The sum of A and B groups was 71.4% of total, and patients were older （P〈0.05）; The level of FBG in A was higher than other groups （P〈0.01）, and TG, LDL-C, APOB, LPA were higher than longer course groups also, but they all were lower than pure diabetic; Compared with pure diabetic group, the levels of BUN, Scr, UA, and UMPR were higher （P〈0.01）, but CysC was no statistically significant （P 〉0.05）. Conclusion：There are glucose and lipoprotein metabolism disorder in patients with diabetic nephropathy, detection of UMPR and plasma lipoprotein is beneficial to early detection of kidney damage.