Fatal fat embolism following amphotericin B lipid complex injection |
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Authors: | Tolentino Lucilene F Tsai Steve F Witt Mallory D French Samuel W |
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Institution: | Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA. |
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Abstract: | A case of amphotericin B lipid complex induced fatal fat embolism is described. A 41-year-old Caucasian man with AIDS was undergoing treatment for cryptococcal meningitis with amphotericin B. His course was complicated by renal failure necessitating a change in therapy to amphotericin B lipid complex (Abelcet). At approximately 48 h, the patient developed tachycardia, tachypnea, respiratory failure, decline in hematocrit, thrombocytopenia, and alteration in mental status. Autopsy findings included fat emboli involving heart, lungs, kidney, and brain. To our knowledge, this is the first case report of a fatal fat embolism caused by intravenous liposome drug delivery. |
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Keywords: | Abelcet Amphotericin B Fat embolism Cryptococcus Gurd's criteria Meningitis AIDS HIV |
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