| 慢性乙型肝炎病毒感染与信号肽酶关系的研究进展 |
| |
| 引用本文： | 廖凤,张晓红. 慢性乙型肝炎病毒感染与信号肽酶关系的研究进展[J]. 国外医学:内科学分册, 2009, 36(9): 528-531 |
| |
| 作者姓名： | 廖凤 张晓红 |
| |
| 作者单位： | 中山大学附属第三医院感染科,广东,广州,510630;中山大学附属第三医院感染科,广东,广州,510630 |
| |
| 摘 要： | 信号肽酶是一组细胞内膜蛋白,在各种蛋白质的成熟过程中,通过切割前蛋白质的信号肽区域而促使其成为成熟的分泌型蛋白,从而发挥关键作用。在乙型肝炎病毒（HBV）感染中,信号肽酶促进Pre—C基因初始产物P25前体向HBeAg的转化,进一步影响慢性HBV感染患者的转归。上述过程受阻时,导致慢性乙型肝炎患者HBeAg阴性,肝硬化及肝癌的发生率随之升高。本文就信号肽酶及慢性HBV感染的关系进展作一综述。
|
| 关 键 词： | 信号肽酶 HBeAg阴性慢性乙型肝炎 p22cr |
Progress in relationship between chronic hepatitis B virus infection and signal peptidase |
| |
| LIAO Feng,ZHANG Xiao-hong. Progress in relationship between chronic hepatitis B virus infection and signal peptidase[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(9): 528-531 |
| |
| Authors: | LIAO Feng ZHANG Xiao-hong |
| |
| Affiliation: | LIAO Feng,ZHANG Xiao-hong.Department of Infectious Disease,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China |
| |
| Abstract: | Signal peptidase complex is a group of inner-membrane protein,which plays an important role in the maturity of all kinds of secretory proteins by cutting off signal sequence from pre-peptide.In the process of hepatitis B virus(HBV)infection,signal peptidase conduct the production of HBeAg from P25-the primary protein encoded by Pre-C gene,ultimately affect the clinical prognosis of patients with HBV infection.If the process fails,those patients will turn to be HBeAg negative and have higher incidence rate o... |
| |
| Keywords: | p22cr |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
