| 运动热应激对大鼠淋巴细胞凋亡氧化应激机制的影响 |
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| 引用本文： | 汪君民,赵阶祥.运动热应激对大鼠淋巴细胞凋亡氧化应激机制的影响[J].辽宁医学院学报,2011,32(2):105-109,113. |
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| 作者姓名： | 汪君民 赵阶祥 |
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| 作者单位： | 1. 福建体育职业技术学院,福建,福州,350003
2. 沛县初级中学,江苏,徐州221600 |
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| 基金项目： | 2009年福建省教育厅课题 |
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| 摘 要： | 目的探讨运动热应激大鼠淋巴细胞凋亡氧化应激的机制。方法健康的雄性SD大鼠36只,随机分为4组,每组9只,即对照组、热应激组、运动组和运动热应激组。实验后测定各组大鼠外周血中氧自由基MDA浓度、SOD活性、淋巴细胞凋亡及其相关调控基因表达的变化情况。结果 8周热应激可对大鼠的产生显著的影响,同时可诱发大鼠体内产生大量的氧自由基,也导致外周血淋巴细胞凋亡显著增加,且其发生与相关调控基因的表达一致;8周的中等负荷的运动训练可降低大鼠体内自由基MDA的浓度,提高SOD的活性,也可以抑制外周血淋巴细胞的凋亡,且其发生与相关调控基因的表达一致;中等负荷运动训练可拮抗热应激诱发的大鼠淋巴细胞凋亡,且其发生与相关基因表达的变化一致。结论中等负荷运动训练拮抗热应激导致的大鼠淋巴细胞凋亡的机制可能是,中等负荷的运动训练通过降低热应激对机体造成氧化应激损伤的反应强度,影响相关凋亡调控基因表达,从而降低大鼠淋巴细胞的凋亡。
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| 关 键 词： | 热应激 运动训练 中等负荷 氧化应激 淋巴细胞凋亡 |
The Effect of Sports and Heat on Oxidative Stress Mechanism of Rats' Lymphocyte Apoptosis |
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| WANG Junmin,ZHAO Jiexiang.The Effect of Sports and Heat on Oxidative Stress Mechanism of Rats' Lymphocyte Apoptosis[J].Journal of Liaoning Medical University (LNMU) Bimonthly,2011,32(2):105-109,113. |
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| Authors: | WANG Junmin ZHAO Jiexiang |
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| Institution: | WANG Junmin1,ZHAO Jiexiang2(1.Fujian Sports Vocational Education and Technical College,Fuzhou 350003 China,2.Peixian Middle School,Xuzhou 221600 China) |
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| Abstract: | Objective To study the effect of sports and heat on oxidative stress mechanism of rats' lymphocyte apoptosis.Methods 36 healthy SD male rats were randomly classified into four groups,that were,the contrast group,the heat stressed group,the sport group and the sport-heat stressed group.After the experiment the rats were measured about their MDA concentration of oxygen free radicals in peripheral blood,SOD activity,lymphocyte apoptosis and related regulation gene expression changes.Results The results showed ... |
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| Keywords: | heat stress sports training medium load oxygen stress lymphocytes apoptosis |
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