| 1种新的天然α-葡萄糖苷酶抑制剂的分离纯化及其活性测定 |
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| 引用本文： | 赵元,张莲英,胡晓燕,崔福爱,吴伟芳,王晓蕾,孙道旭. 1种新的天然α-葡萄糖苷酶抑制剂的分离纯化及其活性测定[J]. 中国生化药物杂志, 2007, 28(1): 20-22 |
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| 作者姓名： | 赵元 张莲英 胡晓燕 崔福爱 吴伟芳 王晓蕾 孙道旭 |
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| 作者单位： | 山东大学,医学院,生物化学与分子生物学研究所,山东,济南,250012 |
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| 摘 要： | 目的从中草药中分离并得到α-葡萄糖苷酶抑制剂。方法中草药地榆通过水提、脱色、离心、离子交换色谱得到地榆多糖。用4-硝基酚-2-D吡喃葡萄糖苷(PNPG)法测定其对不同来源的α-葡萄糖苷酶活性的抑制率。结果地榆多糖显著抑制α-葡萄糖苷酶活性,并且可以降低大鼠餐后血糖浓度。结论地榆多糖是1种新的α-葡萄糖苷酶抑制剂。
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| 关 键 词： | 地榆 多糖 α-葡萄糖苷酶 抑制剂 |
| 文章编号： | 1005-1678（2007）01-0020-03 |
| 收稿时间： | 2005-12-12 |
| 修稿时间： | 2006-01-09 |
Purification and activity of a new natural a-glucosidase inhibitor |
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| ZHAO Yuan,ZHANG Lian-ying,HU Xiao-yan,CUI Fu-ai,WU Wei-fang,WANG Xiao-lei,SUN Dao-xu. Purification and activity of a new natural a-glucosidase inhibitor[J]. Chinese Journal of Biochemical Pharmaceutics, 2007, 28(1): 20-22 |
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| Authors: | ZHAO Yuan ZHANG Lian-ying HU Xiao-yan CUI Fu-ai WU Wei-fang WANG Xiao-lei SUN Dao-xu |
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| Affiliation: | Institute of Biochemistry and Molecular Biology, Medical School of Shandong University, Jinan 250012, China |
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| Abstract: | Purpose To find a a new natrul a-glucosidase Inhibitor from Sanguisorba officinalis L.MethodsSanguisorba officinalis L.polysaccharide were prepared by soaking and decoloration centrifugation and chromatography.In vitro activity was assayed by using the PNPG substrae.In vivo,the Sanguisorba officinalis L.polysaccharide were given to SD rats and the effect on blood glucose level was observed.ResultsSanguisorba officinalis L.polysacharide showed significant a-glucosidase inhibitory and hypoglycemic effect.ConclusionSanguisorba officinalis L.polysacharide is a new natrul a-glucosidase Inhibitor. |
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| Keywords: | Sanguisorba officinalis L. polysaccharide a-glucosidase inhibitor |
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