胰蛋白酶治疗蝰科蛇毒中毒的研究

本文提供了一种局部注射胰蛋白酶治疗蛇伤的方法,在给小白鼠皮下注射致死剂量的竹叶青蛇毒后,立即注射胰蛋白酶可提高存活率68%,注射蝮蛇毒后,立即注射胰蛋白酶可提高存活率67%,注射尖吻蝮蛇毒后立即注射胰蛋白酶可提高存活率57%。临床观察207例,均获治愈,无不良后遗症。该药生产、保存方便,并可装在随身携带的急救注射器中,是蛇伤急救的一个较好药物。为蛇伤治疗增加一种新的方法。

EXPERIMENTAL STUDIES ON TREATMENT OF VIPERIDAE SNAKE BITE WITH TRYPSIN

The local injection of trypsin can be used in clinical practice as a new and effective therapy for snakebite.Our experiments indicate that when a lethal dose of crotalinae snake venom was injected into mice subcutaneously, survival rate increased significantly if a dose of trypin had been injected locally and promptly.When lethal doses of the venoms (Trimeresurus 700 μg, Agkistrodon acutus 450 μg, A. halys 180μg) were injected into mice and trypsin is given, the survival rate is 68%, 57%, 67%.We've treated 207 cases of snakebite without death. The oroduction of trypsin is rather simple and its preservation needs no special condition. Trypsin can be put into portable first-aid auto-injector and can be used after snakebite at the earliest possible time.