帕瑞昔布钠超前镇痛在全脑血管造影术中的应用

目的 观察帕瑞昔布钠超前镇痛在全脑血管造影术中的镇痛效果.方法 择期行全脑血管造影术患者60例,按随机数字表法分为帕瑞昔布钠组(P组)和芬太尼组(F组),每组30例.观察术前(T0)、术中行右颈内动脉造影后即刻(T1)、右椎动脉造影后即刻(T2)、左颈内动脉造影后即刻(T3)、左椎动脉造影后即刻(T4)、术后10 min(T5)的血流动力学变化,记录平均动脉压(MAP)、心率、脉搏血氧饱和度(SpO2).并记录以上各时间点的视觉模拟评分(VAS).结果 两组患者各时间点MAP、心率、VAS比较差异均无统计学意义(P＞0.05).F组T1、T2、T3时SpO2(0.94±0.03、0.95±0.02、0.95±0.02)较P组(0.98±0.01、0.98±0.02、0.98±0.02)明显下降(P＜0.05),其中于T1时有2例SpO2＜0.90.结论 帕瑞昔布钠静脉注射在全脑血管造影术中可获得较为满意的镇痛效果,且无意识障碍、呼吸抑制等不良反应,较芬太尼的使用更为安全.

Abstract：

Objective To evaluate the effects of parecoxib sodium for preemptive analgesia in patients undergoing cerebral angiography. Methods Sixty patients undergoing cerebral angiography were divided into two groups by random digits table with 30 cases in each : group P and group F. Patients in group P received parecoxib sodium 40 mg 30 min before operation, while group F received fentanyl 1 μ g/kg 2 min before operation. The changes of hemodynamics were observed before operation (To), immediately right internal carotid artery angiography during operation (T1), immediately right vertebral artery angiography (T2),immediately left internal carotid artery angiography(T3), immediately left vertebral artery angiography(T4), 10min after operation (T5). The mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2)and visual analogue score (VAS) were recorded at different times during the whole operation. Results There were no significantly differences on MAP, HR and VAS between group P and group F (P ＞ 0.05 ). But the SpO2 at T1 ,T2,T3 in group F (0.94±0.03,0.95±0.02,0.95±0.02) were significantly lower than those in group P (0.98 ± 0.01,0.98 ± 0.02,0.98 ± 0.02 )(P＜0.05 ), and 2 cases SpO2 ＜ 0.90 at Ti. Conclusion Parecoxib sodium administered preemptively provides a nice analgesic effect in patients undergoing cerebral angiography, and is more safe than fentanyl.

Application of parecoxib sodium for preemptive analgesia in patients undergoing cerebral angiography

Objective To evaluate the effects of parecoxib sodium for preemptive analgesia in patients undergoing cerebral angiography. Methods Sixty patients undergoing cerebral angiography were divided into two groups by random digits table with 30 cases in each : group P and group F. Patients in group P received parecoxib sodium 40 mg 30 min before operation, while group F received fentanyl 1 μ g/kg 2 min before operation. The changes of hemodynamics were observed before operation (To), immediately right internal carotid artery angiography during operation (T1), immediately right vertebral artery angiography (T2),immediately left internal carotid artery angiography(T3), immediately left vertebral artery angiography(T4), 10min after operation (T5). The mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2)and visual analogue score (VAS) were recorded at different times during the whole operation. Results There were no significantly differences on MAP, HR and VAS between group P and group F (P ＞ 0.05 ). But the SpO2 at T1 ,T2,T3 in group F (0.94±0.03,0.95±0.02,0.95±0.02) were significantly lower than those in group P (0.98 ± 0.01,0.98 ± 0.02,0.98 ± 0.02 )(P＜0.05 ), and 2 cases SpO2 ＜ 0.90 at Ti. Conclusion Parecoxib sodium administered preemptively provides a nice analgesic effect in patients undergoing cerebral angiography, and is more safe than fentanyl.