| 间硝苯啶的急性及慢性降压作用 |
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| 引用本文： | 王文,张秀娥,刘力生. 间硝苯啶的急性及慢性降压作用[J]. 药学学报, 1992, 27(3): 170-172 |
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| 作者姓名： | 王文 张秀娥 刘力生 |
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| 作者单位： | 中国医学科学院心血管病研究所阜外医院，中国医学科学院心血管病研究所阜外医院，中国医学科学院心血管病研究所阜外医院 北京 100037，北京 100037，北京 100037 |
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| 摘 要： | 给成年SHRsp分别ip间硝苯啶2.5,5及10mg·kg-1后昀显著降低血压,1h达高峰,分别维持2～4,6～8及12h。降压幅度及维持时间均大于等剂量的硝苯啶。慢性实验分别用间硝苯啶10及30mg·kg-1·d-1po给药4周,治疗后降压作用比溶媒对照组强,但与等量硝苯啶无明显差异。
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| 关 键 词： | 间硝苯啶 降压作用 |
| 收稿时间： | 1991-05-17 |
ACUTE AND CHRONIC HYPOTENSIVE EFFECT OF m-NIFEDIPINE |
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| W Wang,XE Zhang,LS Liu. ACUTE AND CHRONIC HYPOTENSIVE EFFECT OF m-NIFEDIPINE[J]. Acta pharmaceutica Sinica, 1992, 27(3): 170-172 |
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| Authors: | W Wang XE Zhang LS Liu |
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| Affiliation: | Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | Three groups of adult stroke--prone spontaneously hypertensive rats (SHRsp) were treated with m-nifedipine (m-Nif) 2.5, 5 and 10 mg.kg-1 by intraperitoneal injection. The systolic blood pressure (SBp) decreased significantly. The hypotensive effect persisted for 2-4, 6-8, and 12 h respectively and the peak effect appeared in 1 h. The range of hypotension was markedly greater than that of nifedipine (Nif). In SHPsp, treatment with m-Nif 10 or 30 mg.kg-1.d-1 for 4 weeks reduced significantly the SBp, but the hypotensive action is about the same as Nif. |
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| Keywords: | m--Nifedipine Antihypertensive action |
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