非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究

目的 探讨超声影像学诊断非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)与血清铁离子和血清铁蛋白浓度的相关性。方法 应用经超声影像学方法诊断的40例非酒精性脂肪肝病者作为病例组及40例健康体检的非酒精性脂肪肝病者作为正常对照组,分别用原子吸收光谱法和放射免疫法检测血清铁和血清铁蛋白浓度。结果 病例组的血清铁、铁蛋白测定值[(105.17±24.52)μg/dL,(146.57±68.28) ng/dL]与对照组[(85.45±26.84) μg/dL,(90.58±49.71) ng/dL]比较,差异有统计学意义(P<0.01)。应用血清铁诊断NAFLD的受试者工作特征(receiver operating characteristic, ROC)曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.69(P<0.01)、123.5 (μg/dL)、82.5%、60%、40 %、17.5%。应用铁蛋白诊断NAFLD的ROC曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.73(P<0.01)、134.9 (ng/dL)、75.0%、72.5%、27.5%、25.0%。结论 NAFLD患者血清铁和铁蛋白水平均出现升高,与超声诊断结果具有明显相关性。

Study on the relationship between the nonalcoholic fatty liver and serum iron and ferritin

Objective To investigate the relationship between the nonalcoholic fatty liver disease (NAFLD) diagnosed by ultrasonography and serum iron and ferritin. Methods Forty patients with NAFLD (case group) and forty normal persons(control group) were examined by ultrasonic diagnosis, the levels of serum iron and serum ferritin were detected by atomic absorption spectrum method and radioimmunoassay respectively. Results The level of serum iron and serum ferritin in case group were (105.17±24.52)μg/dL,(146.57±68.28)ng/dL, the level of serum iron and serum ferritin in control group were (85.45±26.84)μg/dL,(90.58±49.71)ng/dL, respectively.The difference in serum iron and serum ferritin was significantly different between NFALD patients and normal control (P<0.01). The area under receiver operating characteristic (ROC) curve diagnosing NAFLD by serum iron and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.69(P<0.01),123.5 (μg/dL),82.5%,60%,40 %,17.5% respectively. The area under ROC curve diagnosing NAFLD by serum ferritin and the best threshold value and its sensitivity,specificity,mistake diagnosis rate,omission diagnosis rate are 0.73(P<0.01),134.9 (ng/dL),75.0%,72.5%,27.5%,25.0% respectively. Conclusion The levels of serum iron and serum ferritin were higher in NAFLD patients. The rise of serum iron and serum ferritin is coincide with NAFLD diagnosed by ultrasonography.