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| 增生性玻璃体视网膜病变膜剥离标本的免疫组化研究 | |
| 引用本文： | 包永琴,马景学,史丰,郭秀瑾,张文成,继民. 增生性玻璃体视网膜病变膜剥离标本的免疫组化研究[J]. 眼科研究, 2001, 19(3): 214-216 |
| 作者姓名： | 包永琴 马景学 史丰 郭秀瑾 张文成 继民 |
| 作者单位： | 1. 河北医科大学第二医院眼科 石家庄,050000 2. 白求恩国际和平医院病理科 |
| 摘 要： | 目的 探讨不同增生性玻璃体视网膜病变(PVR)的增殖特征。方法采用5种特异性抗体对12例PVR膜样本进行免疫组织化学研究。结果成纤维细胞、神经胶质细胞为参与PVR膜的主要细胞成分，视网膜色素上皮细胞(RPE)、巨噬细胞、纤维连接蛋白和新生血管也参与了PVR的病理过程。结论新生血管主要参与了增生性视网膜血管病变的病理过程。增殖膜中增殖的细胞、细胞外基质和血管成分参与了PVR的病理过程并起着不同的作用。 |
| 关 键 词： | 视网膜疾病 玻璃体 增生性玻璃体视网膜病变 增生型糖尿病视网膜病变 免疫组织化学 |
| 修稿时间： | 2000-06-30 |
Immunohistochemical studyof proliferative vitreoretinopathy membrane |
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| Bao Yongqin, Ma Jingxue,Zhang Wen,et al.. Immunohistochemical studyof proliferative vitreoretinopathy membrane[J]. Chinese Ophthalmic Research, 2001, 19(3): 214-216 | |
| Authors: | Bao Yongqin Ma Jingxue Zhang Wen et al. |
| Affiliation: | Bao Yongqin, Ma Jingxue,Zhang Wen, et al. Department of Ophthalmology,the Second Hospital of He bet Medical University,Shijiazhuang 050000 |
| Abstract: | ObjectiveTo evaluate the characteristics of proliferation in different proliferative vitreoretinopathy(PVR).MethodFive specific antibodies cytokeratin(CK),CD68,fibronectin(FN),factor Ⅷ(F Ⅷ)and actin were used respectively.The specimens from 12 cases with different PVR were studied by immunohistochemical method.ResultsFibroblasts and glial cells were the main cellular components of the PVR membranes,retinal pigment epithelium(RPE)cells,macrophages,fibronectin and neovasculature also took part in the pathological process of PVR.PVR membranes could be divided into fibrovascular membrane and fibrous membrane.ConclusionNeovasculature plays an important role in the pathological process of retinal neovascular diseases such as PVR and Eales diseases.There were interactions among the cellular components,the extra cellular matrix,the vascular elements and the growth factors in the PVR membrances.Each of the membrane components plays a different role in the development of PVR |
| Keywords: | retinal diseases vitreous body proliferative vitreoretinopathy proliferative diabetic retinopathy immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |