| 淫羊藿黄酮治疗骨质疏松性骨折的动物实验研究 |
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| 引用本文： | 罗静华,潘晓华,张戈,何奕欣,刘钟,曾万程. 淫羊藿黄酮治疗骨质疏松性骨折的动物实验研究[J]. 中国中医骨伤科杂志, 2010, 0(9): 10-12,15 |
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| 作者姓名： | 罗静华 潘晓华 张戈 何奕欣 刘钟 曾万程 |
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| 作者单位： | [1]暨南大学第二临床医学院深圳市人民医院放射科,广东深圳518020 [2]暨南大学第二临床医学院深圳市人民医院骨科 ,广东深圳518020 [3]香港中文大学医学院矫形外科及创伤学系,广东深圳518020 |
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| 基金项目： | 深圳市科技计划资助项目（No.2005006／No.200802108） |
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| 摘 要： | 目的:研究淫羊藿黄酮对动物性骨质疏松性骨折愈合的治疗效能。方法:选取36只4月龄C57雌性小鼠先行腰1椎体骨密度检测后切除双侧卵巢(OVX),3周末再次行腰1椎体骨密度检测,建立右股骨中段骨折克氏针内固定模型,随即分成实验组18只(以淫羊藿黄酮化合物20mg/kg/day、钙剂56mg/kg/day喂药,每日1次)和对照组18只(钙剂56mg/kg/d),于骨折第7天,14天和28天分别处死后使用X线摄片观察骨折端愈合情况、用定量CT获取的骨折段皮质骨密度(cBMD)值及其横截面积(CSA)后,计算两者乘积视为骨力学强度指数(BSICSA),比较骨折端力学强度指数(BSICSA)和骨密度(cBMD)变化并作统计学分析。结果:C57雌性小鼠OVX 3周后,定量CT检测的腰1椎体骨密度下降比较具有统计学意义(P0.01),X线片显示实验组和对照组相应时点比较,骨折修复的时间明显缩短;经定量CT获取的骨折段第7天,14天和28天皮质骨力学强度指数(BSICSA)、骨密度(cBMD)变化F组别值为15.72(P0.01)和F组别值为64.05(p0.05),显示出淫羊藿黄酮组和对照组在骨折修复早、中、晚期骨折端密度、强度的比较差异具有统计学意义,淫羊藿黄酮治疗和时间因素均对骨折修复有影响,其中以淫羊藿黄酮治疗因素最有效,Eta组别Eta时间*组别Eta时间;结论:淫羊藿黄酮能有效促进实验性骨质疏松性骨折修复。
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| 关 键 词： | 淫羊藿黄酮 骨质疏松 骨折 修复 定量CT |
Experimental Research of Epimedium-derived-flavonoids for Repairing Osteoporotic Fracture |
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| LUO Jinghua,PAN Xiaohua,△ ZHANG Ge,HE Yixin,LIU Zhong,ZENG Wancheng. Experimental Research of Epimedium-derived-flavonoids for Repairing Osteoporotic Fracture[J]. Chinese Journal of Traditional Medical Traumatology & Orthopeics, 2010, 0(9): 10-12,15 |
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| Authors: | LUO Jinghua PAN Xiaohua △ ZHANG Ge HE Yixin LIU Zhong ZENG Wancheng |
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| Affiliation: | 1Department of Radiology,Shenzhen People＇s Hospital,The Second School of Clinical Medicine,Medical College of Ji＇nan University,Shenzhen 518020,China2Department of Orthopaedics,Shenzhen People＇s Hospital,The Second School of Clinical Medicine,Medical College of Ji＇nan University,Shenzhen 518020,China3Department of Orthopaedic Surgery and Traumatology,The Chinese University of Hong Kong,Hong Kong,China |
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| Abstract: | objective：To observe the repairing effect of Epimedium Flavonoids（EF） on the animal osteoporotic fracture.Methods：Thirty-six female 4-month-old C57 mice after being performed bone mass density（BMD） measurement of 1st lumbar vertebrae with quantitative computed tomography（QCT） at pre-and post-resection of bilateral ovarian（OVX）,and made the open fracture model of right femur with kirsches wire intramedullary fixation,were randomly divided into two groups： experimental group（fed by EF 20mg/kg and calcium 56mg/kg/day once a day） and control group（fed by calcium 56mg/kg/day once a day）.Bone union time,the cortical cross sectional area（CSA） and the cortical BMD were detected by QCT on 7 th,14 nd and 28 th days after been sacrificed respectively.Also,the average of BMD and bone strength index（BSI）（cortical CSA×cortical BMD） around 0.6 cm of fracture site（3 slices） were calculated and statistically analyzed.Results：After three weeks of OVX,the BMD of 1st lumbar vertebrae of the mice were significantly decreased.Compared with the control group,the experimental group＇s BSI（Fgroup=15.72,P0.01） and cortical BMD（Fgroup=64.05,P0.05） were all of significant statistical difference,the effect of interaction of FE factor was the best（EtagroupEtagroup＊timeEtatime）.Conclusion： EF can obviously shorten the repairing time of animal osteoporotic fracture. |
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| Keywords: | Epimedium flavonoids Osteoporotic fracture Repairing Quantitative computed tomography |
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