Notch1受体在乳腺癌组织中的表达及其与临床病理特征的关系

目的 探讨Notch1受体与乳腺癌患者的临床病理特征及预后的关系.方法 应用免疫组化技术检测106例乳腺癌组织中Notch1受体、ER、PR、CerbB-2受体表达情况,分析其与临床病理特征及预后的相关性.结果 乳腺癌组织中Notch1受体表达明显高于癌旁正常组织(P＜0.05);Notch1受体表达与CerbB-2具有相关性(P＜0.05),与ER、PR无显著相关性(P＞0.05);Notch1受体高表达组5年生存率低于低表达组(P＜0.05).结论 乳腺癌组织中Notch1受体表达明显高于癌旁正常组织;Notch1受体表达与CerbB-2具有相关性,推测Notch1受体可能与CerbB-2存在交互作用;Notch1受体高表达与预后不良有关.

The expression of Notch1 receptor in breast cancer and the relation with clinical pathological characteristics

Objective To explore the relationship between Notch1 receptor and the clinical pathological characteristics and prognosis of breast cancer.Methods In 106 cases of breast cancer,immunohistochemical staining method were used to detect the expression of Notch1 receptor,ER,PR,and CerbB-2 in the breast cancer tissue samples,then analyse the relationship between Notch1 receptor and clinical pathological characteristics and prognosis of breast cancer.Results The expression of notch1 receptor in breast cancer is higher than that of the normal breast tissue(P<0.05).There was a significant association of Notch1 receptor with CerbB-2(P<0.05).The 5 years survival rate of breast cancer patients with high Notch1 receptor is lower than patients with low Notch1 receptor.Conclusion The expression of Notch1 in breast cancer is higher than that of the normal breast tissue.The expression of Notch1 is associated with CerbB-2.High Notch1 receptor is associated with poor prognosis.