| 宫颈癌组织端粒酶表达与人乳头瘤病毒感染的相关性 |
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| 引用本文： | 司马妮,蔡丽萍,朱元方,王薇,王世宣,马丁. 宫颈癌组织端粒酶表达与人乳头瘤病毒感染的相关性[J]. 华中科技大学学报(医学版), 2007, 36(3): 326-328 |
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| 作者姓名： | 司马妮 蔡丽萍 朱元方 王薇 王世宣 马丁 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院肿瘤生物医学中心,武汉,430030
2. 南昌大学第一附属医院妇产科,南昌,330006 |
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| 基金项目： | 国家自然科学基金;国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的 探讨宫颈癌组织中端粒酶活性表达与人乳头瘤病毒（human papillomavirus，HPV）感染的关系。方法 采用端粒重复序列扩增（telomere repeat amplification protocal，TRAP）-银染法对45例宫颈癌、30例慢性宫颈炎及20例正常宫颈组织的端粒酶活性进行检测。同时，采用多聚酶链反应（PCR）技术测定上述组织HPV、HPV-16型及HPV-18型的感染情况。结果 宫颈癌组织端粒酶阳性率、HPV和HPV-16检出率高于慢性宫颈炎和正常宫颈组织（P〈0．05）；宫颈癌组端粒酶表达与HPV感染（φ=0．44，P〈0．01）、HPV-16型感染（φ=0．36，P〈0．05）有关联性，与HPV-18型感染未发现关联性（P〉0．OS）。结论 端粒酶的表达、HPV感染包括HPV-16型感染与宫颈癌发生密切相关。
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| 关 键 词： | 宫颈癌 端粒酶 人乳头瘤病毒 |
| 修稿时间： | 2006-06-05 |
Telomerase Activity in Cervical Tissues and Its Correlation to Human Papillomavirus Infection |
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| Sima Ni , Cai Liping , Zhu Yuanfang et al. Telomerase Activity in Cervical Tissues and Its Correlation to Human Papillomavirus Infection[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2007, 36(3): 326-328 |
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| Authors: | Sima Ni Cai Liping Zhu Yuanfang et al |
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| Affiliation: | 1. Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 ;2.Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang 330006 |
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| Abstract: | Objective To investigate the telomerase activity in cervical tissues and its correlation to human papillomavirus(HPV) infection.Methods The telomerase activity was detected by using a modified telomeric repeat amplification protocol(TRAP) assay in cervical tissues in 45 women with cervical cancer,30 women with chronic cervicitis and 20 women with normal cervix.The infection of HPV,HPV-16 and HPV-18 was tested by polymerase chain reaction.Results The telomerase,HPV and HPV-16 positive rate in cervical cancer tissues was higher than that in cervicitis and normal cervix cases(all P<0.05).The HPV and HPV-16 infection was correlated to the presence of telomerase in cervical cancer tissues.Conclusion Activation of telomerase and HPV infection including HPV-16 infection are closely associated with cervical cancer.In cervical cancer activation of telomerase is associated with HPV infection and HPV-16 infection. |
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| Keywords: | cervix neoplasms telomerase human papillomavirus |
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