| 霉酚酸酯对糖尿病大鼠肾组织早期炎症反应的影响 |
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| 引用本文： | 彭琳,张浩,徐果,唐仁泓. 霉酚酸酯对糖尿病大鼠肾组织早期炎症反应的影响[J]. 中南大学学报(医学版), 2008, 33(10): 913-918 |
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| 作者姓名： | 彭琳 张浩 徐果 唐仁泓 |
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| 作者单位： | 中南大学湘雅三医院肾内科，长沙 410013 |
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| 摘 要： | 目的:探讨霉酚酸酯(MMF)对链脲佐菌素(STZ)诱导的糖尿病大鼠肾组织早期炎症反应的影响.方法:36只雄性SD大鼠随机分为正常对照组、糖尿病模型组和MMF治疗组,于4周、14周末每组分别处死6只大鼠,处死前进行24 h尿蛋白定量检测,处死后免疫组织化学染色观察调节激活正常T细胞表达和分泌的细胞分子(RANTES)、单核/巨噬细胞表面特异性标志抗原(ED-1)、Ⅳ型胶原蛋白(Col-Ⅳ)在肾组织中的表达,RT-PCR方法观察RANTES mRNA在肾组织中的表达.结果:MMF可显著抑制大鼠24 h尿总蛋白的排泄,下调肾组织RANTES,ED-1,Col-Ⅳ蛋白及RANTES mRNA的表达.结论:早期应用MMF对糖尿病大鼠的肾保护作用可能与抑制肾脏早期炎症反应有关.
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| 关 键 词： | 糖尿病肾病 霉酚酸酯 炎症反应 |
| 收稿时间： | 2007-11-26 |
Effect of mycophenolate mofetil on the expression of early inflammatory reaction in diabetic rats |
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| PENG Lin,ZHANG Hao,XU Guo,TANG Ren-hong. Effect of mycophenolate mofetil on the expression of early inflammatory reaction in diabetic rats[J]. Journal of Central South University. Medical sciences, 2008, 33(10): 913-918 |
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| Authors: | PENG Lin ZHANG Hao XU Guo TANG Ren-hong |
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| Affiliation: | Department of Nephrology, Third Xiangya Hospital,Central South University, Changsha 410013, China |
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| Abstract: | Objective To investigate the effect of mycophenolate mofetil(MMF) on early inflammatory reaction of renal lesion in streptozotocin(STZ)-induced diabetic rats.Methods Thirty-six male Sprague-Dawley rats were randomly divided into 3 groups after uninephrectomy: normal control group,diabetic model group,and MMF-treated group.Six rats in each group were sacrificed at the 4th week and 14th week after STZ injection.Twenty-four hour urinary protein(24 h Upro) count was measured before death.The expressions of regu... |
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| Keywords: | diabetic nephropathy mycophenolate mofetil inflammatory reaction |
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