肉芽组织破纤维细胞溶酶体包裹相的电镜观察

本文对大白鼠新生肉芽组织内的破纤维细胞进行了超微结构和细胞化学的观察。电镜下可见破纤维细胞内含有大量的各级溶酶体,这些溶酶体的酸性磷酸酶反应均呈阳性。溶酶体不但能与异噬泡和自噬泡融合,还能主动吞噬细胞器和溶酶体等。溶酶体的主动吞噬有三种形式,即突起包裹、内陷包裹和混合包裹。突起包裹的膜由五层结构组成,即两层单位膜,两层亮层,及中央板。大溶酶沐还以出芽、纹窄的形式形成小溶酶体。溶酶体的这种活动可能与细胞吞噬机能的自我调节有关。本文还就破纤维细胞与巨噬细胞之间的关系进行讨论。

ELECTRON MICROSCOPIC OBSERVATION ON LYSOSOMAL WRAPPING MECHANISM OF FIBROCLAST IN GRANULATION TISSUE OF RAT

The fibroclast(one cell type of "fibroblastic system") in wound granulation of rat contains a great deal of primary and secondary lysosomes with positive acid phosphatase reaction.The lysosomes not only fuse with the hetero-and autophagocytic vacuoles, but also phagocytize the organelles and lysosomes by three ways, viz protrusion wrapping, invagination wrapping and complex wrappig.The small lysosomes can be formed from big ones by means of budding and pinching-off .These activities of lysosomes may be related to the autoregulation on the phagocytosis function of fibroclast.The possible relationship between fibroclast and macrophage is discussed.