汞对人体必需元素干扰的研究

对42例汞吸收、2例汞中毒者(尿汞>99.7nmol/L),采用原子吸收光谱法,检测了汞对人体必需五种金属元素代谢的干扰。研究发现,汞时人体必需元素镁、铜具有拮抗作用。汞吸收者血清镁极显著低于对照组(P>0.01)。经驱汞治疗后,血清镁、铜自然上升与对照组无统计学差异(P>0.05),镁离子低下,可出现神经肌纤维兴奋性增高。由此推测,汞引起肌肉震颤的毒理,可能由汞拮抗镁离子低下引起。设想,对汞中毒者采用补镁制剂治疗,是否具有驱汞作用值得探讨。

Study of the mercury interference to the necessary metal elements in human body.

The interference of mercury to the metabolism of five necessary metal elements in human body was studied by using the atomic absorption spectroscopic analysis in 42 cases of mercury absorption and 2 cases of mercury poisoning (the concentration of mercury in urine>99.7nmol/L). It revealed that mercury could counteract with those necessary elements like Mg and Cu, since the serum magnesium in the mercury absorption cases were shown to be obviously lowered than those in the control group (P<0.01). After drive mercury treatment, the magnesium and copper level in serum increased naturally and showed no statistical significance as compared with that of control group (P>0.05). Probably, some sorts of nervemuscle fibre irritability would appear when Mg++ level in serum was low. So it could be inferred that the muscle tremor caused by mercury poisoning might be the result of hypomagnesemia which might be in turn due to the counteraction of mercury to magnesium. It suggested that magnesium supplement in conjunction with the treatment of mercury poisoning would have something to do with drive mercury effect.