闭经患者细胞遗传学检查的临床意义

目的 :分析闭经患者细胞遗传学的检查结果及其临床意义。方法 :对每例闭经患者进行常规妇科检查及细胞遗传学检查 ,包括外周血淋巴细胞培养制备染色体 ,G显带与C显带 ,必要时进行高分辨显带或银染处理 ,或同时用内分泌及超声检查。结果 :2 33例闭经患者中 ,88例染色体异常 ,占 37 78% ,包括染色体数异常、缺失、倒位及嵌合。结论 :染色体异常是闭经的主要原因之一 ,染色体核型分析对确诊闭经的病因、治疗及确定预后必不可少

The analysis of cytogenetic abnormalities for patients with amenorrhea

Objective: To analyse the cytogenetic examinations and their clinical significance for patients with amenorrhea. Methods: The routing gynecologic examination and cytogenetics were performed including pheripheral blood lymphocytes culture for chromosome, and G-banding, C-banding, or if necessary, high resolution banding and silver-staining were treated. In sometimes, endocrine and ultrasound examination were performed simultaneously. Results: There were 88 cases with chromosome abnormally in 233 cases of amenorrhea,account for 37.78%, including number abnormality, deletion, inversion and mosaic type. Conclusions: Chromosome abnormality is one of the main causes of amenorrhea. Karyotype analysis of chromosome are absolutely necessary methods for seeking the cause, therapy and prognosis of patients with amenorrhea.