|
|||||
|
|
| 甲状腺肿瘤癌基因产物p21ras表达的免疫组化研究 | |
| 引用本文： | 孙青,鹿伟,张传森,吴彩志,高钟禹,孙德刚. 甲状腺肿瘤癌基因产物p21ras表达的免疫组化研究[J]. 诊断病理学杂志, 2000, 7(4): 283-284,I071 |
| 作者姓名： | 孙青 鹿伟 张传森 吴彩志 高钟禹 孙德刚 |
| 作者单位： | 1. 第一军医大学病理学博士研究生广州同和 510515 2. 山东省千佛山医院病理科济南 250014 |
| 基金项目： | 本课题受山东省卫生厅医药卫生科研基金资助(920021) |
| 摘 要： | 目的 探讨癌基因产物ｐ２１ｒａｓ表达的意义及在甲状腺肿瘤病理诊断和鉴别诊断中的应用价值。方法 采用免疫组化ＬＳＡＢ法检测了１０例甲状腺腺瘤、１０例不典型腺瘤、２０例乳头状癌、２０例滤泡癌、１０例髓样癌、１０例未分化癌。结果 在甲状腺癌、甲状腺腺瘤和周边正常组织中均有表达，但阳性细胞的量和染色强度有所不同。其分布特点是：癌组织区〉腺瘤区〉正常组织。良恶性肿瘤组间比较Ｐ〈０．０１，差异非常显著。结论 甲状腺癌的发生与ｒａｓ基因的活化和２１ｒａｓ的过量表达关系密切。ｐ２１ｒａｓ的过表达有助于甲状腺良恶性肿瘤的鉴别。 |
| 关 键 词： | 甲状腺肿瘤 pd21ras基因 鉴别诊断 基因表达 |
| 文章编号： | 1007-8096(2000)04-0283-02 |
An immunohistochemical study of p21ras protein in thyroid tumors |
|
| Sun Qing,Lu Wei,Zhang Chuansen,et al.. An immunohistochemical study of p21ras protein in thyroid tumors[J]. Chinese Journal of Diagnostic Pathology, 2000, 7(4): 283-284,I071 | |
| Authors: | Sun Qing Lu Wei Zhang Chuansen et al. |
| Affiliation: | Sun Qing,Lu Wei,Zhang Chuansen,et al. Department of Pathology,Qian-Fo-Shan Hospital,Jinan 250014 |
| Abstract: | Objective To evaluate the significance and practical value of p21ras protein expression in the diagnosis of thyroid tumors. Methods A monoclonal antibody p21ras and LSAB immunohistochemical method were used to detect its expression in 10 cases of thyroid adenoma, 10 atypical adenoma, 20 papillary carcinoma, 20 follicular carcinoma, 10 medullary carcinoma and 10 undifferentiated carcinoma.Results Positive cells of p21ras were found in thyroid carcinomas, adenomas and normal thyroid tissues, but there was a significance of the staining intensity between thyroid adenomas and carcinomas. Conclusion Over-expression of p21ras is closely related to thyroid tumorgenesis and can be used as a useful marker in differential diagnosis of thyroid tumors. |
| Keywords: | Thyroid tumors p21ras Immunohistochemistry Differential diagnosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |