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新型聚氨酯材料的血液相容性及毒理学研究
引用本文:刘金成,易定华,杨剑,贾林才,郝解玲,胡巧侠. 新型聚氨酯材料的血液相容性及毒理学研究[J]. 生物医学工程与临床, 2004, 8(1): 5-7
作者姓名:刘金成  易定华  杨剑  贾林才  郝解玲  胡巧侠
作者单位:1. 第四军医大学西京医院心血管外科,陕西,西安,710032
2. 山西省化工研究所,山西,太原,030021
摘    要:目的 通过对新型聚氨酯材料的血液相容性及毒理性研究,评价新型聚氨酯作为人工心脏辅助泵体材料的可行性。方法 实验包括溶血实验、刺激试验及全身急性毒性试验,观察72h组织及动物反应情况。结果新型聚氨酯材料溶血指数小于5%,血液相容性良好,无明显毒性。结论此种新型聚氨酯符合人工心脏辅助泵体材料的要求。

关 键 词:血液相容性 毒理学 聚氨酯材料 人工心脏
文章编号:1009-7090(2004)01-0005-03
修稿时间:2003-02-27

Study on Blood Compatibility and Toxicology of a Novel Polyurethane
LIU JinCheng ,YI DingHua ,YANG Jian ,JIA LinCai ,HAO JieLing ,HU QiaoXia. Study on Blood Compatibility and Toxicology of a Novel Polyurethane[J]. Biomedical Engineering and Clinical Medicine, 2004, 8(1): 5-7
Authors:LIU JinCheng   YI DingHua   YANG Jian   JIA LinCai   HAO JieLing   HU QiaoXia
Affiliation:LIU JinCheng 1,YI DingHua 1,YANG Jian 1,JIA LinCai 2,HAO JieLing 2,HU QiaoXia 1
Abstract:Objective To evaluate the blood compatibility and toxicological characteristics of a novel polyurethane.Me thods The evaluation tests including hemolysis,stimulation and systemic acute toxic tests were performed. The polyurethane extracts were injected subentaneous in rabbits and IV in mouse,then the histology and animal responses in 72 h were studied. Results The hemolytic indexes of the polyurethane was lower than 5 %. The blood compatibility of this material was good, toxicity was not found. Primary skin irritation test showed no erythema,eschar and edema.Conclusion The novel polyurethane meets the requirements of material characteristics in mechanical heart assist pump.
Keywords:polyurethane  blood compatibility  toxicology
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