| 基于肝星状细胞分子机制的抗肝纤维化研究进展 |
| |
| 引用本文： | 韦燕飞,彭岳,谢海源,赵铁建. 基于肝星状细胞分子机制的抗肝纤维化研究进展[J]. 世界华人消化杂志, 2009, 17(17) |
| |
| 作者姓名： | 韦燕飞 彭岳 谢海源 赵铁建 |
| |
| 作者单位： | 广西中医学院基础医学院生理学教研室,广西壮族自治区南宁市,530001;广西中医学院基础医学院生理学教研室,广西壮族自治区南宁市,530001;广西中医学院基础医学院生理学教研室,广西壮族自治区南宁市,530001;广西中医学院基础医学院生理学教研室,广西壮族自治区南宁市,530001 |
| |
| 基金项目： | 国家自然科学基金,广西壮族自治区自然科学基金,广西研究生教育创新计划 |
| |
| 摘 要： | 肝星状细胞(hepatic stellate cells,HSCs)是细胞外基质(extra cellular matrix,ECM)的主要来源,在肝纤维化形成中起关键性作用,ECM主要成分包括各型胶原、糖蛋白、蛋白多糖等.HSCs通过分泌多种细胞因子影响并加重肝纤维化的进程. 近年国内外围绕以HSCs凋亡和促进胶原的降解为靶标的抗肝纤维化研究成为热点,为肝纤维化的防治寻找突破口.
|
| 关 键 词： | 肝星状细胞 细胞外基质 细胞因子 分子机制 |
Advances in anti-fibrosis at the molecular level based on hepatic stellate cells |
| |
| Yan-Fei Wei,Yue Peng,Hai-Yuan Xie,Tie-Jian Zhao. Advances in anti-fibrosis at the molecular level based on hepatic stellate cells[J]. World Chinese Journal of Digestology, 2009, 17(17) |
| |
| Authors: | Yan-Fei Wei Yue Peng Hai-Yuan Xie Tie-Jian Zhao |
| |
| Abstract: | Extra cellular matrix (ECM),which plays a key role in the formation of liver fibrosis,mainly comes from the hepatic stellate cells (HSCs). The major components of ECM,includes collagens,glycoproteins,polysaccharides,etc. HSCs can in-fluence or accelarate the process of liver fibrosis through secretion of many cytokines. Recently,many scientists home and abroad focus on HSCs apoptosis and degradation of collagen as a target,in order to find a breakthrough for the prevention and treatment of liver fibrosis. |
| |
| Keywords: | Hepatic stellate cells Extra cellular matrix Cytokines Molecular mechanisms |
| 本文献已被 万方数据 等数据库收录！ |
|
