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| 胎盘生长因子的病理学作用 | |
| 引用本文： | 张翀,孙家邦. 胎盘生长因子的病理学作用[J]. 国际外科学杂志, 2008, 35(10): 711-714 |
| 作者姓名： | 张翀 孙家邦 |
| 作者单位： | 首都医科大学宣武医院普外科,北京,100053 |
| 摘 要： | 肿瘤的血管生成是肿瘤发生、发展、转移过程中的重要环节,受多种因子调节.胎盘生长因子是血管内皮生长因子家族中的一员,氨基酸序列和VEGF-A有高度的同源性,以VEGFR-1为受体.胎盘生长因子(placenta srowth factor,PLGF)在生理条件下,在成年人、成熟组织中表达弱,但在病理条件下,如缺氧、外伤、肿瘤等,是一种重要的病理性血管生成因子,在病理性妊娠、特别是多种肿瘤组织中有高表达,而且和肿瘤的病理程度相关,对其研究具有重要的临床价值. |
| 关 键 词： | 胎盘生长因子 病理学 血管生成 |
The pathological role of placenta growth factor |
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| ZHANG Chong,SUN Jia-Bang. The pathological role of placenta growth factor[J]. International Journal of Surgery, 2008, 35(10): 711-714 | |
| Authors: | ZHANG Chong SUN Jia-Bang |
| Abstract: | Angiogenesis is an important step during the occuring, development and metabsis of tumor which is regulated by some factors. PLGF is one of the VEGF family. It is homologous with VEGF-A, VEC,-FR-1 is its receptor. Although it expresses weakly during physiology. PLGF is an important pathologic angio-genesis factor at the condition such as anoxia, truma or tumor. Becanse its expression becomes strong at path-ologic cyophoria and many kinds of tumors, PLGF has a good value in clinic reasereh. |
| Keywords: | placenta growth factor pathology angiogenesis |
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