p-eIF4E和p-Mnk1在头颈鳞状细胞癌中的表达及临床意义

目的探讨磷酸化真核细胞翻译起始因子4 E （ p- eukaryotic translation initiation factor 4 E, p-eIF4 E ）和磷酸化MAPK作用激酶1（ p- MAP kinase integrating kinase, p-Mnk 1 ）在头颈鳞状细胞癌（ head and neck squamous cell cancer, HNSCC）中的表达及其临床意义。方法HNSCC组织芯片结合免疫组化S．P法检测P-eIF4E和P—Mnkl在60例HNSCC和35例癌旁组织中的蛋白表达，分析两者表达与HNSCC临床病理特征的相关性。结果p-elF4E和P—Mnkl在HNSCC中的阳性表达率显著高于癌旁组织（P〈0．01），P-eIF4E的阳性表达率与HNSCC的分化程度、临床分期显著相关（P〈0．05）；有淋巴结转移HNSCC的P．Mnkl阳性表达率显著高于无淋巴结转移者（P〈0．05）。HNSCC组织中P-eIF4E和P-Mnkl表达呈显著正相关（r=0．375，P=0．005）。结论HNSCC组织中P-eIF4E和P—Mnkl异常表达与HNSCC的临床进展和浸润转移相关，两者在肿瘤发生发展过程中有协同作用。

Clinical significance of the expression of p-eIF4E and p-Mnk1 in HNSCC

Objective To study the expression of p-eIF4 E and p-Mnk 1 in the head and neck squamous cell carcinoma （HNSCC） and its clinical significance. Methods Expression of p-eIF4E and p-Mnk 1 was detected in 60 samples of HNSCC and 35 of peri-cancer tissues by tissue microarray immunohistochemical S-P method. Results The positive expression rates of p-eIF4E and p-Mnkl in HNSCC were significantly higher than those of peri-cancer tissues （both P 〈 0.01 ）. The expression of p-eIF4E was correlated with pathological grading and clinical stages of HNSCC （ P 〈 0.05 ）. The expression rate of p-Mnkl in HNSCC with lymphatic metastasis was significantly higher than that without metastasis （P 〈 0.05 ）. In addition, the expression of p-eIF4E was positively correlated with that of p-Mnk 1 in HNSCC （ r =0. 361 , P = 0. 005 ） . Conclusions The abnormal expression of p-eIF4 E and p-Mnk 1 is related to the development, invasion and metastasis of HNSCC. Co-expression of p-eIF4E and p-Mnkl has a possible synergistic action that may promote the carcinogenic process of HNSCC.