| 通塞脉片对动脉粥样硬化大鼠CD40及CD40L表达的影响 |
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| 引用本文： | 朱青,胡晨,蒋凤荣,殷书梅,卞慧敏. 通塞脉片对动脉粥样硬化大鼠CD40及CD40L表达的影响[J]. 中华中医药杂志, 2011, 0(1): 160-162 |
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| 作者姓名： | 朱青 胡晨 蒋凤荣 殷书梅 卞慧敏 |
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| 作者单位： | 南京中医药大学中医药研究院;江苏南星药业有限责任公司江苏省中药药效与安全性评价重点实验室; |
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| 基金项目： | 国家自然科学基金(No.30873401)~~ |
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| 摘 要： | 目的:观察通塞脉片(TSM)对大鼠动脉粥样硬化(AS)的治疗作用并探讨其作用机制。方法:通过饲喂高脂饲料加维生素D3建立大鼠AS模型,给予TSM治疗后,观察血管形态学、白细胞表面分化抗原40(CD40)、白细胞表面分化抗原40配体(CD40 Ligand,CD40L)在血管中表达以及血清中炎症因子C反应蛋白(CRP)变化。结果:TSM可以显著改善AS大鼠动脉形态学的改变,降低其血清中炎性因子CRP的含量:模型组(8.19±2.82)mg/L,辛伐他汀组(5.19±1.89)mg/L,TSM组高剂量(5.17±2.60)mg/L,低剂量(5.24±2.52)mg/L(P<0.05),同时抑制血管中CD40、CD40L的表达(P<0.05,P<0.01)。结论:TSM通过降低体内的炎症水平而达到治疗AS作用。
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| 关 键 词： | 动脉粥样硬化 通塞脉片 C反应蛋白 白细胞表面分化抗原40 白细胞表面分化抗原40配体 |
Effect of TSM on expression of CD40 and CD40L in AS Rats |
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| ZHU Qing,HU Chen,JIANG Feng-rong,YIN Shu-mei,BIAN Hui-min. Effect of TSM on expression of CD40 and CD40L in AS Rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(1): 160-162 |
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| Authors: | ZHU Qing HU Chen JIANG Feng-rong YIN Shu-mei BIAN Hui-min |
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| Affiliation: | ZHU Qing1,HU Chen1,JIANG Feng-rong1,YIN Shu-mei2,BIAN Hui-min1(1Research Institute of Chinese Medicine and Pharmacology,Nanjing University of Chinese Medicine,Nanjing 210029,China,2Jiangsu Nanxing Pharmaceutical Co.Ltd.,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,China) |
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| Abstract: | Objective: To examine the therapeutic effect of Tongsaimai Pills(TSM)on antiatherosclerosis(AS)and the mechanism involved.Methods: Athero-sclerosis model was established by feeding rats with high fat diet and VD3.After eight weeks of TSM administration,C-reactive protein(CRP) was measured.CD40 and CD40 Ligand(CD40L)were examined by immunohistochemistry.Morphological changes of aorta were observed under gross,light and electron microscopes.Results: Morphological changes in AS were altered by TSM.Serum CRP le... |
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| Keywords: | Artherosclerosis Tongsaimai Pills C-reactive protein |
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