涎腺嗜酸细胞腺瘤和嗜酸细胞腺癌的临床病理分析

目的：探讨涎腺嗜酸细胞肿瘤的临床病理特征、鉴别诊断、治疗和预后。 方法：对23例嗜酸细胞腺瘤、15例嗜酸细胞腺癌的临床特点、病理表现及组织化学、免疫组织化学和电子显微镜观察结果进行观察、分析，同时对所有病例进行随访，分析患者的治疗和预后。结果：嗜酸细胞腺瘤多发生于腮腺（95.6%），23例患者经局部切除后均无复发，诊断主要依赖组织病理学检查，即肿瘤由嗜酸细胞构成，包膜完整。嗜酸细胞腺癌亦为腮腺多发，是一种恶性程度较高的涎腺肿瘤，局部复发（50%）、区域淋巴结转移（50%）和远处转移率（28.6%）都较高，根治性手术是首选治疗方案，该肿瘤的诊断除依据常规病理特点外，组织化学、免疫组织化学和电子显微镜观察均可证明嗜酸细胞胞浆颗粒为大量线粒体，可辅助诊断，其中免疫组织化学方法因特异性强、简单易行更加适用。结论：涎腺嗜酸细胞肿瘤较少见，嗜酸细胞腺瘤预后较好，肿瘤切除后很少复发；嗜酸细胞腺癌预后差，根治性手术是首选治疗方案，肿瘤诊断主要依靠组织病理学检查，线粒体免疫组织化学有助于诊断和鉴别诊断。

A clinicopathologic study on oncocytoma and oncocytic carcinoma of the salivary glands

Objective:To investigate the clinicopathologic features,differential diagnosis,treatment and prognosis of oncocytoma and oncocytic carcinoma of the salivary glands.Methods: The clinicopathologic features were studied in 23 cases of oncocytomas and 15 cases of oncocytic carcinomas,and immunohistochemical staining as well as electron microscopy were performed.Results: Most oncocytomas occurred in the parotid gland(95.6%) with no recurrence.The diagnosis was made based on histopathological features.Oncocytic c...