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| 大黄素季铵盐类衍生物的设计合成与抗癌活性评价 | |
| 引用本文： | 洪芳,胡建达,王文峰. 大黄素季铵盐类衍生物的设计合成与抗癌活性评价[J]. 海峡药学, 2012, 24(9): 254-256 |
| 作者姓名： | 洪芳 胡建达 王文峰 |
| 作者单位： | 1. 福州大学化学化工学院 福州350108 2. 福建医科大学附属协和医院 福州350001 |
| 基金项目： | 福建省科技厅重点项目资助(2010Y0033);福建省光催化重点实验室开放课题(038019) |
| 摘 要： | 通过大黄素的3位烷基化,1位保护及与叔胺反应实现了对大黄素的化学修饰.目标产物是一个季铵盐.测试了目标产物对白血病细胞Molt-4和人淋巴瘤细胞CA46的抗癌活性.结果表明目标产物的抗癌活性比大黄素约高10倍. |
| 关 键 词： | 大黄素 季铵盐 抗白血病 |
Design synthesis and anticancer activity evaluation of quaternary ammonium salt of emodin derivative |
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| HONG Fang , HU Jian-da , WANG Wen-feng. Design synthesis and anticancer activity evaluation of quaternary ammonium salt of emodin derivative[J]. Strait Pharmaceutical Journal, 2012, 24(9): 254-256 | |
| Authors: | HONG Fang HU Jian-da WANG Wen-feng |
| Affiliation: | 1.College of Chemistry and Chemical Engineering,Fuzhou University,Fuhzou 350108,China;2.Union Hospital of Fujian Medical University,Fuzhou 350001,China) |
| Abstract: | The chemical modification of emodin has been carried through the alkylation on 3-position,protection on 1-position and reaction with tertiary amine.The target compound is a quaternary ammonium salt.The anticancer activities of the target compound against to CA46 lymphoma cells and Molt-4 leukemia cells have been tested.The result shows that the anticancer activity of the target compound is about 10 times higher than emodin. |
| Keywords: | Emodin Quaternary ammonium salt Antileukemia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |