克班宁脂质体抗心律失常作用的研究

目的：比较克班宁(Crebanine,Cre)及其脂质体的抗心律失常作用。方法：分别采用氯化钡、乌头碱引起的大鼠心律失常模型,比较克班宁(Crebanine,Cre)及Cre脂质体抗心律失常作用。结果：对氯化钡所致的心律失常,Cre脂质体高、低剂量组(5mg/kg、2.5mg/kg),均能使恢复窦性节律鼠数、维持窦性节律至20min以上鼠数显著高于生理盐水组(P<0.01)；Cre脂质体(5mg/kg)能使乌头碱所致大鼠VP、VT、VF、死亡时间显著延迟,与NS相比,差异具有显著性意义(P<0.01)；与同剂量Cre溶液相比,Cre脂质体的VF出现的时间明显延长(P<0.01)。结论：克班宁脂质体对氯化钡所致的心律失常有一定治疗作用、对乌头碱引起的心律失常有一定预防作用。

Research on Antiarrhythmic Effects of Crebanine Liposomes

OBJECTIVE To compare the anti-arrhythmic effects of crebanine(Cre) and Cre liposomes. METHODS Used the arrhythmia model of rats caused by barium chloride or aconitine, to compare antiarrhythmic effects of Cre and Cre liposomes. RESULTS To arrhythmia induced by barium chloride, both of the high or low dose group of Cre liposomes (5, 2.5 mg·kg^-1) could restore rats'' sinus rhythm, and maintain rats'' sinus rhythm to 20 min, the result was significantly higher than the saline group (P<0.01); Cre liposomes (5 mg·kg^-1) could significantly delay the time of VP, VT, VF death which caused by aconitine, compared with NS, the difference was of great significance(P<0.01); compared with the same dose of Cre solution, VF appear time of Cre liposomes was longer (P<0.01). CONCLUSION Crebanine liposomes have some therapeutic effects on arrhythmia induced by barium chloride, and it also have a preventive effect on arrhythmia induced by aconitine.