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大肠癌组织中基质金属蛋白酶-9及其抑制物的表达和临床意义
引用本文:郭德智,张宝良. 大肠癌组织中基质金属蛋白酶-9及其抑制物的表达和临床意义[J]. 中国综合临床, 2009, 25(2). DOI: 10.3760/cma.j.issn.1008-6315.2009.02.012
作者姓名:郭德智  张宝良
作者单位:河北省唐山市工人医院普外腔镜科,063000
基金项目:唐山市科学技术研究与发展指导计划课题 
摘    要:目的 探讨大肠癌组织中基质金属蛋白酶-9(MMP-9)及其抑制物基质金属蛋白酶抑制剂-1(TIMP-1)的表达和临床意义.方法 采用PowerVision二步法免疫组织化学染色检测42例大肠癌组织及其癌旁组织中MMP-9和TIMP-1表达情况并分析其与临床病理参数的关系.结果 MMP-9在大肠癌组织中表达率明显高于癌旁组织(69.1%与45.2%,P=0.009);TIMP-1在大肠癌组织中表达率明显高于癌旁组织(61.9%与40.5%,P=0.004).MMP-9的表达与Dukes分期、浸润深度、淋巴结转移正相关(rs=0.429,P=0.005;rs=0.372,P=0.015;rs=0.372,P=0.015);TIMP-1的表达与Dukes分期、浸润深度、淋巴结转移正相关(rs=0.394,P=0.010;rs=0.382,P=0.013;rs=0.382,P=0.013).MMP-9的表达与TIMP-1的表达呈正相关(rs=0.641,P<0.001).结论 MMP-9和TIMP-1在大肠癌发生发展中起重要作用,联合检测二者对大肠癌侵袭转移的预测、预后评估及指导合理的综合治疗等具有重要的临床意义.

关 键 词:大肠癌  基质金属蛋白酶9  组织基质金属蛋白酶抑制因子-1  免疫组织化学

Expression and clinical significance of matrix metalloproteinase and matrix metulloproteinase tissue inhibiting factor-1 in colorectal carcinomas
GUO De-zhi,ZHANG Bao-liang. Expression and clinical significance of matrix metalloproteinase and matrix metulloproteinase tissue inhibiting factor-1 in colorectal carcinomas[J]. Clinical Medicine of China, 2009, 25(2). DOI: 10.3760/cma.j.issn.1008-6315.2009.02.012
Authors:GUO De-zhi  ZHANG Bao-liang
Abstract:Objective To investigate the expression and clinicopathological significance of matrix metallo-proteinase(MMP-9) and matrix metalloproteinase tissue inhibiting factor-1 (TIMP-1) in colorectal carcinomas.Methods Immunohistochemistry (PowerVision method) in the paraffin embedded tissue samples was used to deter-mine MMP-9 and TIMP-1 in 42 colorectal carcinomas and its adjacent normal colorectal mucosa.The relationship of their expression with some clinicopathological characteristics was analyzed.Results MMP-9 and TIMP-1 were both significantly overexpressed in colorectal carcinomas compared with its adjacent normal colorectal mucosa(69.1% and 61.9% vs.45.2% and 40.5% ,P =0.009 and P =0.004) ,and MMP-9 was positively associated with the re-gional lymph node metastasis,bowel wall invasion and Dukes stage(rs=0.372,P =0.015;rs =0.372,P =0.015;rs = 0.429,P = 0.005).TIMP-1 was positively associated with Dukes stage, bowel wall invasion and regional lymph node metastasis (rs = 0.394, P = 0.010;rs= 0.382,P = 0.013rs = 0.382, P = 0.013 ).There was a positive corre-lafion between the expression of MMP-9 and TIMP-1 (rs=0.641, P <0.001).Conclusion MMP-9 and TIMP-1 may play a key role in colorectal carcinogenesis.Examination of MMP-9 and TIMP-1 expression may have an impor-tant significance for evaluating prognosis, predicting of invasion and metastasis and comprehensive therapy.
Keywords:Colorectal carcinoma  Matrix metalloproteinase-9  Matrix metalloproteinase tissue inhibi-ting factor-1  Immunohistochemistry
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