Distribution,metabolism, and excretion of musk xylene in rats |
| |
| Authors: | Ken-ichiro Minegishi Seiichi Nambaru Masamichi Fukuoka Akira Tanaka Tomoko Nishimaki-Mogami |
| |
| Affiliation: | (1) Division of Xenobiotic Metabolism and Disposition, National Institute of Hygienic Sciences, 1-18-1 Kamiyoga, Setagaya, 158 Tokyo, Japan;(2) Division of Biological Chemistry and Biochemicals, National Institute of Hygienic Sciences, Tokyo, Japan |
| |
| Abstract: | ![]()
Distribution, metabolism and excretion of musk xylene (MX) were investigated in male Wistar rats. Urinary and fecal excretion accounted for 10 and 75% of the dose (70 mg/kg), respectively, on day 7 after orally administration of3H-MX to rats. Total residue of radioactivity in tissues on day 7 was less than 2.0% of the administered dose. The highest concentration was found in adipose tissue and the second was in liver. Some metabolites of MX were identified using GC-MS and NMR after purification by column or thin layer chromatography of feces, bile and urine extracts. MX, 2-NH2-MX, 2-Ac-MX, 2-NH2-3-CH2OH-MX, and 2-NH2-5-tert-BuOH-MX were found in feces, bile and urine. 4-NH2-MX and metabolite X were found in feces and urine. 4-NH2-3-CH2OH-MX was found in urine. HO-MX was found in bile. The major route of excretion for MX was the feces via bile. The reduction of the 2-nitro group of MX to the amino group was a key step in metabolism. Further metabolism of 2-NH2-MX may proceed by decreased steric hindrance of functional group. |
| |
| Keywords: | Artificial fragrance Musk xylene Metabolism (rat) Distribution Metabolites |
| 本文献已被 SpringerLink 等数据库收录！ |
|
