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| 非酒精性脂肪性肝病患者血清脂肪细胞因子研究进展 | |
| 引用本文： | 王萍[综述] 李强[审校]. 非酒精性脂肪性肝病患者血清脂肪细胞因子研究进展[J]. 实用肝脏病杂志, 2014, 0(3): 329-332 |
| 作者姓名： | 王萍[综述] 李强[审校] |
| 作者单位： | 哈尔滨医科大学附属第二临床医院内分泌代谢病科/糖尿病医院/哈尔滨医科大学激素与内分泌疾病重点实验室,哈尔滨市150086 |
| 基金项目： | 黑龙江省科技攻关项目（编号：GA07C303107） |
| 摘 要： | 作为代谢综合征的肝脏表现，非酒精性脂肪性肝病（NAFLD）的主要特征为胰岛素抵抗（IR）和肝脂肪沉积。脂肪细胞因子作为脂肪细胞分泌的多肽，在 NAFLD 和 IR 的发病中发挥着重要的作用。本文综述了瘦素、脂联素、视黄醇结合蛋白4、成纤维细胞生长因子21和趋化素等新发现的细胞因子与 NAFLD 发病之间的关系。 |
| 关 键 词： | 非酒精性脂肪性肝病 脂肪细胞因子 胰岛素抵抗 |
Adipocytokines in nonalcoholic fatty liver diseases |
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| Affiliation: | Wang Ping, Li Qiartg.( Departnvznt of Endocrinology and Metabolism Dis- eases,Second Affiliated Hospital,Harbin Medical University,Harbin 150086) |
| Abstract: | Nonalcoholic fatty liver disease（NAFLD） is a part of hepatic manifestation of the metabolic syndrome. Its main features are fat deposition in liver and insulin resistance （IR）. Adipokines, a group of polypeptides secreted by adipocyte cells, play an important role in the pathogenesis of NAFLD and IR. In this paper,the focus is emphasized on the roles of adipokines in NAFLD,such as leptin, adiponectin, retinol binding protein 4,fibroblast growth factor 21,chemerin and other emerging factors. |
| Keywords: | Non-alcoholic fatty liver disease Adipocytokines Insulin resistance |
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