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| HPLC测定阿苯达唑有关物质 | |
| 引用本文： | 孙春艳, 赵亚萍, 郭江红. HPLC测定阿苯达唑有关物质[J]. 中国现代应用药学, 2012, 29(3): 264-267. |
| 作者姓名： | 孙春艳 赵亚萍 郭江红 |
| 作者单位： | 1.湖北省食品药品监督检验研究院，武汉 430064 |
| 摘 要： | 目的 建立高效液相色谱法测定阿苯达唑有关物质。方法 采用资生堂MGⅡ C18柱(250 mm×4.6 mm，5 μm)色谱柱；流动相：磷酸二氢铵溶液(1.67 mg·mL-1)-甲醇(40∶60)；检测波长：290 nm。 结果 样品中的杂质均能很好检出，各杂质与主峰之间的分离度良好，检测限为0.228 6 ng。结论 该方法简单快速，专属性强，结果准确，可用作阿苯达唑有关物质检查。 |
| 关 键 词： | 阿苯达唑 有关物质 高效液相色谱法 |
| 收稿时间： | 2011-05-05 |
| 修稿时间： | 2011-10-05 |
Determination of Related Substances in Albendazole by HPLC |
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| SUN Chunyan, ZHAO Yaping, GUO Jianghong. Determination of Related Substances in Albendazole by HPLC[J]. Chinese Journal of Modern Applied Pharmacy, 2012, 29(3): 264-267. | |
| Authors: | SUN Chunyan ZHAO Yaping GUO Jianghong |
| Affiliation: | 1.Hubei Province Institute for Food and Drug Control, Wuhan 430064, China |
| Abstract: | OBJECTIVE To establish an HPLC method for determination of related substances in albendazole. METHODS PAK C18 HPLC packed column（MG II, 250 mm × 4.6 mm, 5 um）was used, the mobile phase was ammonium dihydrogen phosphate-methanol（40 ： 60） and the determination wavelength was 290 rim. RESULTS Albendazole and related substances could be well isolated. The detection limit was 0.228 6 ng. CONCLUSION The method is simple, rapid, accurate and suitable for examinating the related substances of albendazole. |
| Keywords: | albendazole related substances HPLC |
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