一个男运动员的性腺机能低下与富含胡萝卜素饮食的关系(英文)

目的:报道了一个年轻男运动员大量摄入胡萝卜素后引发性腺机能低下的独特病例。病例报告:一名20岁的患者,在先前一年里坚持自己设计的高胡萝卜素、低动物脂肪的饮食,就诊时症状为肌肉逐渐萎缩、身体活动能力以及性欲减低、勃起功能下降。临床上,他表现出明显的胡萝卜素过量的体征:掌心和脚底都呈黄色。当他的饮食正常化二周后,胡萝卜素 B 值达到了正常范围的上限。方法:在恢复均衡饮食前和恢复均衡饮食3、6和12个月后,分别进行下丘脑、垂体和睾丸功能的重复刺激测试。结果:在均衡饮食数月后,促性腺激素和性腺类固醇由最初测得的非常低的基础值和刺激值逐渐恢复正常,并且胡萝卜素 B 值也有所恢复。诊断9—12个月后,荷尔蒙分泌物和性反应完全恢复。结论:这是第一个与摄入过量胡萝卜素有关的下丘脑式性腺机能低下的病例。

Association of carotene rich diet with hypogonadism in a male athlete

Aim:To report on a unique case of hypogonadism associated with excessive carotene intake in a young male athlete. Case report:A 20-year-old patient presented with a gradual decline in muscular and physical activity,sexual interest and erectile ability associated with a high in carotene and low in animal fat diet of his own design a year prior to the clinical manifestations.Clinically,he presented with very overt signs of carotene excess:his palms and soles were yellow.Moreover,2 weeks after normalization of his diet,carotene B levels were at the upper end of the normal range.Methods:Repeated stimulation tests of hypothalamic,pituitary and testicular function were performed before and at 3,6 and 12 months after the introduction of a balanced diet.Results:Very low basal and stimulated values for gonadotropins and gonadal steroids were found at the initial evaluation with a progressive recovery shown after months of a balanced diet and carotene B restoration.Complete androgen secretion and sexual response recovery were observed only after 9-12 months from diagnosis.Conclusion:This is the first report associating excessive carotene intake with a hypothalamic form of hypogonadism in a young man.(Asian J Androl 2006 Jul;8:488-492)