| 组织蛋白酶D与基质金属蛋白酶-9在口腔鳞癌的表达 |
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| 引用本文： | 陈晓艺,张白凌,陈少杰.组织蛋白酶D与基质金属蛋白酶-9在口腔鳞癌的表达[J].福建医科大学学报,2006,40(6):560-562. |
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| 作者姓名： | 陈晓艺 张白凌 陈少杰 |
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| 作者单位： | 1. 福建医科大学,附属第二医院,皮肤科,泉州,362000
2. 福建医科大学,附属口腔医院,病理科,福州,350004 |
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| 摘 要： | 目的 探讨组织蛋白酶D(CD)与基质金属蛋白酶-9(MMP-9)在人类口腔鳞癌(OSCC)中的表达意义. 方法 采用免疫组织化学SP法检测76例OSCC组织与20例癌旁正常口腔黏膜的CD与MMP-9水平. 结果 CD和MMP-9在OSCC中的阳性表达率分别为81.6%和77.6%,显著高于癌旁正常口腔黏膜(P＜0.01).两者均与OSCC浸润深度和淋巴结转移密切相关,浸润越深,其表达越强(P＜0.05);有淋巴结转移的病例,其阳性率明显高于无转移者(P＜0.05);MMP-9表达还与组织分化程度密切相关,分化程度越低,其表达越强(P＜0.05).OSCC组织中CD和MMP-9表达具有一定的一致性. 结论 CD和MMP-9的阳性表达与OSCC的侵袭转移有关.
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| 关 键 词： | 组织蛋白酶D 基质金属蛋白酶类 口腔肿瘤 免疫组织化学 预后 |
| 文章编号： | 1672-4194(2006)06-0560-03 |
| 修稿时间： | 2006年5月31日 |
Expression of Cathepsin D and MMP-9 in Oral Squamous Cell Carcinoma |
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| Chen Xiaoyi,Zhang Bailing,Chen Shaojie.Expression of Cathepsin D and MMP-9 in Oral Squamous Cell Carcinoma[J].Journal of Fujian Medical University,2006,40(6):560-562. |
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| Authors: | Chen Xiaoyi Zhang Bailing Chen Shaojie |
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| Abstract: | Objective To investigate the expression and the significance of cathepsin D(CD) and matrix metalloproteinase-9(MMP-9) in oral squamous cell carcinoma(OSCC).Methods The expression of CD and MMP-9 was detected with S-P immunohistochemical method in 76 patients with primary OSCC and 20 with normal oral mucosa adjacent to carcinoma.Results The positive expression rates of CD((81.6%)) and MMP-9(77.6%) in OSCC were significantly higher than those in normal oral mucosa(P< 0.01).There was a highly significant correlation between the expression of CD and MMP-9 in OSCC and the tumor invasive depth and lymph node metastasis(P<0.05),the positive expression of MMP-9 was related to histologic grade(P<0.05).Conclusion The expression of CD and MMP-9 in OSCC is closely related to the tumor invasion and metastasis. |
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| Keywords: | cathepsin D matrix metalloproteinases mouth neoplasms immunohistochemistry prognosis |
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