美罗培南持续泵入治疗ICU呼吸机相关性肺炎观察

目的：观察ICU治疗呼吸机相关性肺炎时使用美罗培南静脉连续泵入的临床疗效。方法：将呼吸机相关性肺炎患者58例随机分为持续泵注组和间断输注组2组。持续泵注组28例，采用美罗培南3 g/24h静脉持续输注；间断输注组30例，采用美罗培南1 g在0.5 h内输注，每8 h输注1次。结果：持续泵注组治疗成功率提高，患者机械通气时间缩短，患者经济支出有降低。2组不良反应的发生无显著性差异。结论：美罗培南持续泵注治疗呼吸机相关性肺炎疗效更佳，可减少医疗费用，且安全性好。

Clinical Efficacy of Meropenem by Continuous Infusion in Ventilator-associated Pneumonia

Objective:To evaluate the clinical efficacy of continuous infusion of meropenem for the treatment of ventilator-associated pneumonia.Methods:Fifty-eight patients with ventilator-associated pneumonia were randomly divided into two groups.One group received meropenem by continuous infusion (3 g over 24 h), the other by intermittent infusion (1 g over 30 min every 6 h).Results:The group receiving medication by continuous infusion showed a greater clinical cure rate,shorter mechanical ventilation time and less economic cost than the group treated with intermittent infusion.There were no significant differences of adverse events between the two groups.Conclusions:Meropenem administered by continuous infusion have more clinical efficacy,less economic cost than intermittent infusion,and the administration by continuous infusion is safe.