Promoter methylation of RASSF1A and DAPK and mutations of K-ras,p53, and EGFR in lung tumors from smokers and never-smokers |
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| Authors: | Yang Liu Weimin Gao Jill M Siegfried Joel L Weissfeld James D Luketich Phouthone Keohavong |
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| Affiliation: | (1) Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, Suite 350, 100 Technology Drive, 15219 Pittsburgh, PA, USA;(2) Department of Environmental Toxicology and The Institute of Environmental and Human Health, Texas Tech University, 79409 Lubbock, TX, USA;(3) Department of Pharmacology, University of Pittsburgh, 15261 Pittsburgh, PA, USA;(4) Department of Epidemiology, University of Pittsburgh, 15213 Pittsburgh, PA, USA;(5) Department of Surgery, University of Pittsburgh, 15213 Pittsburgh, PA, USA;(6) University of Pittsburgh Cancer Institute, 15213 Pittsburgh, PA, USA |
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| Abstract: | Background Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor suppressor genes are frequent in lung tumors from smokers but rare in those from never-smokers. In this study, we analyzed promoter methylation in the ras-association domain isoform A (RASSF1A) and the death-associated protein kinase (DAPK) genes in lung tumors from patients with primarily non-small cell lung cancer (NSCLC) from the Western Pennsylvania region. We compare the results with the smoking status of the patients and the mutation status of the K- ras, p53, and EGFR genes determined previously on these same lung tumors. |
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