| 聚均苯四甲酸十二烷二醇酯的合成及表征 |
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| 引用本文： | 徐凯,梁纪军,李留法,王中彦,莫凤奎.聚均苯四甲酸十二烷二醇酯的合成及表征[J].现代中西医结合杂志,2009,18(12). |
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| 作者姓名： | 徐凯 梁纪军 李留法 王中彦 莫凤奎 |
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| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016
2. 沈阳药科大学药学院,辽宁,沈阳,110016;石药集团中诺药业,石家庄,有限公司,河北,石家庄,050011 |
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| 摘 要： | 目的合成聚均苯四甲酸十二烷二醇酯,并对其进行表征。方法采用溶液缩聚法合成聚酯,单因素考察法优化工艺;红外光谱法和核磁共振氢谱进行表征。结果合成工艺为:溶剂原料比为2∶1,PMDA与DCD的摩尔比例为1∶1,催化剂为氯化亚锡,反应时间为10 h。红外光谱显示合成物结构中含有聚酯的基本官能集团和羧基,核磁氢谱显示生成了二元酯。结论成功合成了聚均苯四甲酸十二烷二醇酯。
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| 关 键 词： | 聚酯 PMDA 溶液缩聚法 合成 表征 |
Synthesis and characterization of poly (pyromellitic acid-dodecanediol) ester |
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| Xu Kai,Liang Jijun,Li Liufa,Wang Zhongyan,Mo Fengkui.Synthesis and characterization of poly (pyromellitic acid-dodecanediol) ester[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2009,18(12). |
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| Authors: | Xu Kai Liang Jijun Li Liufa Wang Zhongyan Mo Fengkui |
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| Abstract: | Objective It is to synthesize and characterize the poly(pyromellitic acid-dodecanediol) ester.Methods Liquid condensation polymerization method was used to synthesize the polyester,and its technology was optimized by single factor investigation method;its construction was corroborated by FT-IR and 1H-NMR.Results The optimized technology was as follow: the ratio between solvent and raw material was 2 to 1,molar ratio between PMDA and DCD was 1 to 1,catalyst was SnCl2,and reaction time was 10 h.The result of FI-IR revealed that the composite had carboxy group and basic function group of polyester;and the result of 1H-NMR showed it had formed diester.Conclusion A new pharmaceutical grade poly(pyromellitic acid-dodecanediol) ester was achieved. |
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| Keywords: | PMDA |
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