ENDOTHELIAL CELL ADHESION MOLECULES IN PSORIASIS |
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| Authors: | May-Lian Lee Tony To Ellen Nicholson Leslie Schrieber |
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| Affiliation: | May-Lian Lee, M Med, FACD, Department of Dermatology, Royal North Shore Hospital.;Tony To, A.App.Sc., Sutton Rheumatism Research Laboratory, Sydney University Department of Rheumatology, Royal North Shore Hospital, Sydney.;Ellen Nicholson, B.Sc (Hons)., Sutton Rheumatism Research Laboratory, Sydney University Department of Rheumatology, Royal North Shore Hospital, Sydney.;Leslie Schrieber, MD, FRACP, Sutton Rheumatism Research Laboratory, Sydney University Department of Rheumatology, Royal North Shore Hospital, Sydney. |
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| Abstract: | Skin biopsies from patients with psoriasis and normal controls were examined for the expression of cell adhesion molecules including intercellular adhesion molecule-1 (ICAM-1) endothelial leukocyte adhesion molecule-1 (ELAM-1), HECA-452 and 4D10, using an immunoperoxidase techique. This study demonstrates that psoriatic skin exhibits a wide variety of markers of endothelial cell activation which are either induced or increased expression (ICAM-1, ELAM-1 & 4D10). Moreover, ICAM-1 & HECA-452 are also on leukocytes. These antigens may facilitate the adhesion of inflammatory cells to endothelium and antigen-presenting cells in psoriatic skin. Thus, they may play a role in faciliating the infiltration of leukocytes into psoriatic skin. |
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| Keywords: | Endothelial cell adhesion molecules psoriasis |
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