杞元膏加味对2型糖尿病大鼠糖脂代谢的影响

目的:观察杞元膏加味对2型糖尿病大鼠血糖、血脂的影响.方法:Wistar雄性大鼠70只,随机抽取10只作为正常对照组(生理盐水),其余以高糖高脂饲料诱导加链脲佐菌素( STZ) 35 mg· kg -1 ip建立2型糖尿病模型,7d后选取成模大鼠50只,按血糖高低分为模型对照组(生理盐水)、药物对照组(盐酸二甲双胍0.5 g·kg-1)、杞元膏加味组(低、中、高剂量组以生药计分别为2.5,5,10 g·kg-1),每组10只.连续ig给药3周后,观察各组大鼠血糖、血脂、血清胰岛素等变化.结果:空腹血糖杞元膏加味低、中、高剂量组由模型组(22.00±1.30) mmol· L-1降为(16.00+1.22),(14.63±1.30),(13.25±1.28)mmol·L-1(P ＜0.05);血清胰岛素杞元膏加味低、中、高剂量组由模型组(11.86±0.79)μg·L-1升为(16.17±0.99),(18.11±0.75),(19.07±0.77) μg· L-1 (P ＜0.05);杞元膏加味低、中、高剂量组均能降低大鼠甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆同醇(LDL-C) (P ＜0.05),升高高密度脂蛋白胆固醇(HDL-C) (P ＜0.05).结论:杞元膏加味对糖尿病大鼠有降低血糖,改善血脂,升高血清胰岛素的作用.

Effect of Qiyuan Cream Flavored on Blood Glucose and Blood Lipids in Rats with Type 2 Diabetes

Objective:To observe the effect of Qiyuan cream flavored(QYCF) on blood glucose and blood lipids in the diabetic rats with type 2 diabetes.Method: Ten of 70 Wistar male rats were selected as normal group,other rats were used to establish type 2 diabetic model by the injection of streptozotocin(STZ) of 35 mg·kg-1through intraperitoneal with high sugar and high fat for 7 days.Then,the rats were divided into model group treated with normal saline,0.5 g·kg-1metformin hydrochloride group,2.5 g·kg-1 dosage of QYCF,5 g·kg-1 dosage group of QYCF and 10 g·kg-1 dosage group QYCF.After 3 weeks of administration level of blood glucose and lipids was observed.Result: Compared with fasting blood glucose(FBG) level in model group(22.00±1.30)mmol·L-1,FBG level in low,medium and high dose QYCF group was(16.00±1.22),(14.63±1.30),(13.25±1.28) mmol·L-1,respectively(P<0.05).Compared with serum insulin level of model group(11.86±0.79) μg·L-1,serum insulin level of QYCF groups was(16.17±0.99),(18.11±0.75),(19.07±0.77) μg·L-1,respectively(P<0.05).All the three QYCF groups could reduce the serum total cholesterol,triglyceride concentration and low density lipoprotein(P<0.05),raising high density lipoprotein(P<0.05) in rats.Conclusion: QYCF has the effects of reducing blood glucose,improving blood lipids and raising serum insulin.