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A substance P-containing hypothalamic neuronal system projects to the median eminence |
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| Authors: | G.B. Makara I. Kakucska V. Lenoir B. Kerdelhue M. Palkovits |
| Affiliation: | 1. Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest Hungary;2. Laboratoire des Hormones Polypeptidiques, C.N.R.S., F-91190 Gif-sur-Yvette France;1. Human Systems Neuroscience Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States;2. Graduate Program for Neuroscience, Boston University and School of Medicine, Boston, MA, United States;3. Neural Systems Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States;1. Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA;2. Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX, USA;3. Department of Psychology, The University of Texas at Austin, Austin, TX, USA;4. Johns Hopkins University School of Medicine, Baltimore, MD, 21298, USA;5. Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA |
| Abstract: | Immunoreactive substance P (SPi) was measured in the various hypothalamic structures and amygdala one week after placing a cut around the medial basal hypothalamus (MBH). SPi content decreased in the stalk-median (SME), anterior and posterior parts of the arcuate nucleus (inside the isolated region) as well as in the paraventricular nucleus (outside the cut), while there was no change in the posteromedial amygdaloid nucleus. We suggest that there is a tuberoinfundibular neuronal system containing SPi with cell bodies in the MBH and terminals in the SME. In addition, nerve fibers containing SPi from outside the MBH may reach both the SME and the arcuate nucleus and might influence neuroendocrine regulation. |
| Keywords: | substance P tuberoinfudibular neuron stalk median eminence hypothalamus deafferentation |
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