亚硒酸钠联合泼尼松治疗亚急性甲状腺炎临床观察

目的:探讨亚硒酸钠联合泼尼松对亚急性甲状腺炎患者的影响.方法:对2004年9月-2008年8月在本院诊治的78例亚甲炎患者进行随机对照前瞻性研究.对照组有2例失访,37例完成观察,治疗组39例.两组均予以泼尼松治疗(30 mg/d),治疗组加服亚硒酸钠,总疗程8周左右.结果:经过8周治疗,第2、4周亚硒酸钠组的血沉低于对照组(P＜0.05),亚硒酸钠组2 h、6 h和24 h吸碘率的高于对照组(P＜0.01),而复发率低于对照组(P＜0.05).结论:亚硒酸钠可以缩短亚急性甲状腺炎病程,减少复发率.

Clinical observation of sodium selenite combination prednisone treatment on subacute thyroiditis

AIM:To investigate the effects of sodium selenite combination prednisone in patients with subacute thyroiditis (SAT).METHODS:78 cases of SAT were studied with a randomized controlled prospective study from Sep 2004 to Aug 2008 in our hospital.In control group,2 eases were lost,37 patients were completed the observation,the treatment group were 39 cases.Prednisone was treated in both groups,sodium selenite was served in treatment group,with a total course of about 8 weeks.RESULTS:After 8 weeks of treatment,the erythrocyte sedimentation rate (ESR) of sodium selenite group was lower than that of control group at 2th and 4th weeks (P ＜ 0.05),~(131)I uptake rate of sodium selenite group was higher than that of control group at 2 h,6 h and 24 h (P ＜0.01),while the relapse rate was lower than that of the control group (P ＜ 0.05).CONCLUSION:The sodium selenite can shorten the course of subacute thyroiditis and reduce the relapse rate.