咪唑安定辅助硬膜外阻滞的临床研究

目的 :研究咪唑安定用于硬膜外麻醉时的镇静、抗焦虑、消除内脏牵拉反应痛及对呼吸、循环的影响。方法 :硬膜外麻醉下行下腹部手术病人 4 0例 ,随机分为咪唑安定 (Ⅰ )组和氟芬合剂(Ⅱ )组 ,每组 2 0例。Ⅰ组 :咪唑安定负荷剂量 0 .0 5mg/kg ,然后用 0 .0 5mg/kg .h行泵持续输注。Ⅱ组 :氟派啶 0 .0 5kg ,芬太尼 1ug/kg肌注。 结果 :Ⅰ组的镇静、抗焦虑、消除内脏牵拉反应痛的作用明显强于Ⅱ组 ,P <0 .0 5。两组对血流动力学及呼吸均无明显影响 ,P >0 .0 5。结论 :咪唑安定能安全的辅助于硬膜外麻醉 ,能有效的增强镇静、抗焦虑和消除内脏牵拉痛 ,对呼吸和血流动力学无明显影响。

Clinical study of midazolam in epidural anesthesia

Objective:Clinical study of midazolam sedative action, anti-anxiety,decrease entrails pain,and the influence of haemodynamic and respiratory under epidural anesthesia. Methods:40 patients were divided randomly into two groups(N=20).Group Ⅰwas injected midazolam 0.05／mg.kg,then continuos transfusion 0.05mg／kg．h by micropump. Group Ⅱwas injected fentanyl 1 ug／kg and droperidol 0.05mg／kg. Results: The group Ⅰhave significant better sedadive action, anti-anxiety, decrease entrails pain than the Ⅱ group, P＜0.05. Both two groups have no significant influence on haemodynamic and respiratory, P＞0.05. Conclusions: Midazolam can increase sedative action, anti-anxiety,decreaes entrails pain,have no significant influence on haemodynamic and respiratory under epidural anesthesia. It is can safety used in epidural anesthesia.