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Estimation of instantaneous flow from the indicator-dilution curve after bolus injection of indicator |
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| Authors: | E. A. von Reth M. J. F. P. Pluym A. A. van Steenhoven J. Poulis A. Versprille |
| Affiliation: | (1) Application Department, Medical Systems Division, Philips International BV, PO Box 218, 5600 MD Eindhoven, The Netherlands;(2) Departments of Physics and Mechanical Engineering, Eindhoven University of Technology, Den Dolech 2, PO Box 513, 5600 MB Eindhoven, The Netherlands;(3) Pathophysiological Laboratory, Department of Pulmonary Diseases, Erasmus University, Burgemeester Oudlaan 50, PO Box 1738, 3000 DR Rotterdam, The Netherlands |
| Abstract: | The indicator-dilution technique is commonly used to determine mean flow estimates. The estimation of instantaneous flow from the shape of an indicator-dilution curve is the objective of this study. Based on a mixing chamber approach to the flow system, a mathematical relationship is derived to reconstruct momentary flow from an indicator-dilution curve. This relationship is verified in a model setup both with only constant flow and with a sinusoidal flow variation superimposed. This method proved to give good flow estimates for limited values of flow parameters. Also, some preliminary experiments were performed in a pulsating flow system simulating heart action. The results were promising although the method proved to be very sensitive to baseline offset. |
| Keywords: | Indicator dilution Instantaneous flow Mixing chamber model |
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