华蟾素联合化疗治疗晚期恶性肿瘤56例疗效分析

目的：观察华瞻素联合化疗治疗恶性肿瘤的疗效。方法：经病理确诊的晚期恶性肿瘤患者56例，随机分为两组。治疗组28例，采用华蟾素联合化疗；对照组28例，应用单纯化疗。结果：治疗组CR4例、PR11例、CR＋PR为53．57％（15／28）。对照组CR2例，PR10例，CR＋PR为42．85％（12／28）。治疗组静脉炎发生率及生活质量高于对照组，但消化道反应及骨髓抑制率均低于对照组。结论：华蟾素配合化疗治疗恶性肿瘤效果明显，且安全可靠，值得临床推广。

Aanlysis of the therapeutic effects of cinobufotal in combined with chemotherapy for advanced malignant tumors with 56 cases

Objective：To evaluate the therapeutic effects of cinobufotalin combined with chemo therapy for advanced malignant tumors. Methods ： 48 cases of advanced malignant tumor pat ients were treated during 2007, 5 to 2009, 3. They were divided at random into 2 groups： Therapy group 28 cases, using cinobufotalin combined with chemotherapy and control group 28 cases, using chemotherapy alone. The therapeutic effects and the side reactions were compared. Results ： In the therapy group. 4 cases showed complete response （CR） and 11 cases of partial response （PR）. The total response rate as 53.57 %, while in the control group, there were only 2 case of complete response and 10 cases of partial response, CR＋ PR w as 42.85 %.Aomong the side react ions, phlebit and life quality in the therapy group were hihger than that of the control group, while digestive system reactions of digestive system and bone marrow depression were less than contol group. Conclusion：The use of cinobufotalin combined with chemotherapy is a safe and rehable treatment for advanced malignant tumors.